Vitamin B5 and succinyl-CoA improve ineffective erythropoiesis in SF3B1 mutated myelodysplasia

Patients with myelodysplastic syndrome and ring sideroblasts (MDS-RS) present with symptomatic anemia due to ineffective erythropoiesis that impede their quality of life and increase morbidity. More than 80% of patients with MDS-RS harbor splicing factor 3B subunit 1 (SF3B1) mutations, the founder a...

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Detalles Bibliográficos
Autores principales: Mian, Syed A, Philippe, Céline, Maniati, Eleni, Protopapa, Pantelitsa, Bergot, Tiffany, Piganeau, Marion, Nemkov, Travis, Bella, Doriana Di, Morales, Valle, Finch, Andrew J, D’Alessandro, Angelo, Bianchi, Katiuscia, Wang, Jun, Gallipoli, Paolo, Kordasti, Shahram, Kubasch, Anne Sophie, Cross, Michael, Platzbecker, Uwe, Wiseman, Daniel H, Bonnet, Dominique, Bernard, Delphine G, Gribben, John G, Rouault-Pierre, Kevin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7614516/
https://www.ncbi.nlm.nih.gov/pubmed/36857430
http://dx.doi.org/10.1126/scitranslmed.abn5135

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