Total Syntheses of (+)-Waixenicin A, (+)-9-Deacetoxy-14,15-deepoxyxeniculin, and (−)-Xeniafaraunol A

[Image: see text] The first asymmetric total synthesis of the Xenia diterpenoid waixenicin A, a potent and highly selective TRPM7 inhibitor, is reported. The characteristic trans-fused oxabicyclo[7.4.0]tridecane ring system was constructed via a diastereoselective conjugate addition/trapping sequenc...

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Autores principales: Steinborn, Christian, Huber, Tatjana, Lichtenegger, Julian, Plangger, Immanuel, Wurst, Klaus, Magauer, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7614607/
https://www.ncbi.nlm.nih.gov/pubmed/37192136
http://dx.doi.org/10.1021/jacs.3c03366

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