Point estimation for adaptive trial designs II: practical considerations and guidance

In adaptive clinical trials, the conventional end-of-trial point estimate of a treatment effect is prone to bias, that is, a systematic tendency to deviate from its true value. As stated in recent FDA guidance on adaptive designs, it is desirable to report estimates of treatment effects that reduce...

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Detalles Bibliográficos
Autores principales: Robertson, David S., Choodari-Oskooei, Babak, Dimairo, Munya, Flight, Laura, Pallmann, Philip, Jaki, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7614609/
https://www.ncbi.nlm.nih.gov/pubmed/37021359
http://dx.doi.org/10.1002/sim.9734

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7614609/
https://www.ncbi.nlm.nih.gov/pubmed/37021359
http://dx.doi.org/10.1002/sim.9734

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