RNA polymerase II-associated proteins reveal pathways affected in VCP-related amyotrophic lateral sclerosis

Valosin-containing protein (VCP) is a hexameric ATPase associated with diverse cellular activities. Genetic mutations in VCP are associated with several forms of muscular and neuronal degeneration, including amyotrophic lateral sclerosis (ALS). Moreover, VCP mediates UV-induced proteolysis of RNA po...

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Detalles Bibliográficos
Autores principales: Rafiee, Mahmoud-Reza, Rohban, Sara, Davey, Karen, Ule, Jernej, Luscombe, Nicholas M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7614746/
https://www.ncbi.nlm.nih.gov/pubmed/36789492
http://dx.doi.org/10.1093/brain/awad046

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