Cargando…

Perforin-2 is a pore-forming effector of endocytic escape in cross-presenting dendritic cells

During initiation of antiviral and antitumour T cell-mediated immune responses, dendritic cells (DCs) cross-present exogenous antigens on MHC class I. Cross-presentation relies on the unique “leakiness” of endocytic compartments in DCs, whereby internalised proteins escape into the cytosol for prote...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rodríguez-Silvestre, Pablo, Laub, Marco, Krawczyk, Patrycja A., Davies, Alexandra K., Schessner, Julia P., Parveen, Reejuana, Tuck, Benjamin J., McEwan, William A., Borner, Georg H.H., Kozik, Patrycja
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7614779/ https://www.ncbi.nlm.nih.gov/pubmed/37347855 http://dx.doi.org/10.1126/science.adg8802

Ejemplares similares

To Kill But Not Be Killed: Controlling the Activity of Mammalian Pore-Forming Proteins
por: Krawczyk, Patrycja A., et al.
Publicado: (2020)

A Screen for Endocytic Motifs
por: Kozik, Patrycja, et al.
Publicado: (2010)

The pore conformation of lymphocyte perforin
por: Ivanova, Marina E., et al.
Publicado: (2022)

Small Molecule Enhancers of Endosome-to-Cytosol Import Augment Anti-tumor Immunity
por: Kozik, Patrycja, et al.
Publicado: (2020)

Lipid specificity of the immune effector perforin
por: Hodel, Adrian W., et al.
Publicado: (2020)

Diarylthiophenes as inhibitors of the pore-forming protein perforin
por: Miller, Christian K., et al.
Publicado: (2016)

Perforin-2 clockwise hand-over-hand pre-pore to pore transition mechanism
por: Jiao, Fang, et al.
Publicado: (2022)

Conformational Changes during Pore Formation by the Perforin-Related Protein Pleurotolysin
por: Lukoyanova, Natalya, et al.
Publicado: (2015)

Caspase-7 and acid sphingomyelinase: partner repairmans of gasdermin and perforin pores
por: Jin, Ke, et al.
Publicado: (2022)

Multivariate proteomic profiling identifies novel accessory proteins of coated vesicles
por: Borner, Georg H.H., et al.
Publicado: (2012)

The proteasome biogenesis regulator Rpn4 cooperates with the unfolded protein response to promote ER stress resistance
por: Schmidt, Rolf M, et al.
Publicado: (2019)

Dissociation of membrane binding and lytic activities of the lymphocyte pore-forming protein (perforin)
Publicado: (1987)

Repurposing a pore: highly conserved perforin-like proteins with alternative mechanisms
por: Ni, Tao, et al.
Publicado: (2017)

Subversion of the Endocytic and Secretory Pathways by Bacterial Effector Proteins
por: Weber, Mary M., et al.
Publicado: (2018)

Perforin pores in the endosomal membrane trigger release of endocytosed granzyme B to the cytosol of target cells
por: Thiery, Jerome, et al.
Publicado: (2011)

NKG2D Recognition and Perforin Effector Function Mediate Effective Cytokine Immunotherapy of Cancer
por: Smyth, Mark J., et al.
Publicado: (2004)

Ancient but Not Forgotten: New Insights Into MPEG1, a Macrophage Perforin-Like Immune Effector
por: Bayly-Jones, Charles, et al.
Publicado: (2020)

Organelle tethering, pore formation and SNARE compensation in the late endocytic pathway
por: Davis, Luther J., et al.
Publicado: (2021)

Visualization of perforin/gasdermin/complement-formed pores in real cell membranes using atomic force microscopy
por: Liu, Yuying, et al.
Publicado: (2018)

Perforin and hematological cancer
por: Covas, Dimas Tadeu
Publicado: (2011)

Endocytic membrane repair by ESCRT-III controls antigen export to the cytosol during antigen cross-presentation
por: Gros, Marine, et al.
Publicado: (2022)

Plasmodium Perforin-Like Protein Pores on the Host Cell Membrane Contribute in Its Multistage Growth and Erythrocyte Senescence
por: Garg, Swati, et al.
Publicado: (2020)

Cryo‐EM structures of perforin‐2 in isolation and assembled on a membrane suggest a mechanism for pore formation
por: Yu, Xiulian, et al.
Publicado: (2022)

The major CD8 T cell effector memory subset in the normal and Chlamydia trachomatis-infected human endocervix is low in perforin
por: Ibana, Joyce A, et al.
Publicado: (2012)

Two-pore channels as master regulators of membrane trafficking and endocytic well-being
por: Vassileva, Kristin, et al.
Publicado: (2020)

Perforin Gene Transfer Into Hematopoietic Stem Cells Improves Immune Dysregulation in Murine Models of Perforin Deficiency
por: Carmo, Marlene, et al.
Publicado: (2015)

The combination of the prodrugs perforin-CEBPD and perforin-granzyme B efficiently enhances the activation of caspase signaling and kills prostate cancer
por: Chuang, C-H, et al.
Publicado: (2014)

The Rab5 Effector Rabankyrin-5 Regulates and Coordinates Different Endocytic Mechanisms
por: Schnatwinkel, Carsten, et al.
Publicado: (2004)

An enzymatic cascade of Rab5 effectors regulates phosphoinositide turnover in the endocytic pathway
por: Shin, Hye-Won, et al.
Publicado: (2005)

Endocytic trafficking of GAS6–AXL complexes is associated with sustained AKT activation
por: Poświata, Agata, et al.
Publicado: (2022)

Adenosine leakage from perforin-burst extracellular vesicles inhibits perforin secretion by cytotoxic T-lymphocytes
por: Tadokoro, Hiroko, et al.
Publicado: (2020)

Properties of a purified pore-forming protein (perforin 1) isolated from H-2-restricted cytotoxic T cell granules
Publicado: (1986)

Genomic organization of the mouse pore-forming protein (perforin) gene and localization to chromosome 10. Similarities to and differences from C9
Publicado: (1990)

Perforin expression in lymphocytes infiltrated to human colorectal cancer.
por: Nakanishi, H., et al.
Publicado: (1991)

The endocytic activity of dendritic cells
Publicado: (1995)

Perforin: an important player in immune response
por: Osińska, Iwona, et al.
Publicado: (2014)

Benzenesulphonamide inhibitors of the cytolytic protein perforin
por: Spicer, Julie A., et al.
Publicado: (2017)

Perforin-Like Proteins of Apicomplexan Parasites
por: Sassmannshausen, Juliane, et al.
Publicado: (2020)

Perforin and resistance to SARS coronavirus 2
por: Cunningham, Louise, et al.
Publicado: (2020)

Deep and fast label-free Dynamic Organellar Mapping
por: Schessner, Julia P., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_u1etnuscn6o898v1rksvleahpu