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The role of single protein elasticity in mechanobiology

In addition to biochemical signals and genetic considerations, mechanical forces are rapidly emerging as a master regulator of human physiology. Yet the molecular mechanisms that regulate force-induced functionalities across a wide range of scales, encompassing the cell, tissue or organ levels, are...

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Autores principales: Beedle, Amy EM, Garcia-Manyes, Sergi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7614781/
https://www.ncbi.nlm.nih.gov/pubmed/37469679
http://dx.doi.org/10.1038/s41578-022-00488-z
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author Beedle, Amy EM
Garcia-Manyes, Sergi
author_facet Beedle, Amy EM
Garcia-Manyes, Sergi
author_sort Beedle, Amy EM
collection PubMed
description In addition to biochemical signals and genetic considerations, mechanical forces are rapidly emerging as a master regulator of human physiology. Yet the molecular mechanisms that regulate force-induced functionalities across a wide range of scales, encompassing the cell, tissue or organ levels, are comparatively not so well understood. With the advent, development and refining of single molecule nanomechanical techniques, enabling to exquisitely probe the conformational dynamics of individual proteins under the effect of a calibrated force, we have begun to acquire a comprehensive knowledge on the rich plethora of physicochemical principles that regulate the elasticity of single proteins. Here we review the major advances underpinning our current understanding of how the elasticity of single proteins regulates mechanosensing and mechanotransduction. We discuss the present limitations and future challenges of such a prolific and burgeoning field.
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spelling pubmed-76147812023-07-19 The role of single protein elasticity in mechanobiology Beedle, Amy EM Garcia-Manyes, Sergi Nat Rev Mater Article In addition to biochemical signals and genetic considerations, mechanical forces are rapidly emerging as a master regulator of human physiology. Yet the molecular mechanisms that regulate force-induced functionalities across a wide range of scales, encompassing the cell, tissue or organ levels, are comparatively not so well understood. With the advent, development and refining of single molecule nanomechanical techniques, enabling to exquisitely probe the conformational dynamics of individual proteins under the effect of a calibrated force, we have begun to acquire a comprehensive knowledge on the rich plethora of physicochemical principles that regulate the elasticity of single proteins. Here we review the major advances underpinning our current understanding of how the elasticity of single proteins regulates mechanosensing and mechanotransduction. We discuss the present limitations and future challenges of such a prolific and burgeoning field. 2023-01 2022-10-24 /pmc/articles/PMC7614781/ /pubmed/37469679 http://dx.doi.org/10.1038/s41578-022-00488-z Text en https://creativecommons.org/licenses/by/4.0/This work is licensed under a CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/) International license.
spellingShingle Article
Beedle, Amy EM
Garcia-Manyes, Sergi
The role of single protein elasticity in mechanobiology
title The role of single protein elasticity in mechanobiology
title_full The role of single protein elasticity in mechanobiology
title_fullStr The role of single protein elasticity in mechanobiology
title_full_unstemmed The role of single protein elasticity in mechanobiology
title_short The role of single protein elasticity in mechanobiology
title_sort role of single protein elasticity in mechanobiology
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7614781/
https://www.ncbi.nlm.nih.gov/pubmed/37469679
http://dx.doi.org/10.1038/s41578-022-00488-z
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