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Antibacterial activity of inverse vulcanized polymers

Inverse vulcanization is a bulk polymerization method for synthesizing high sulfur content polymers from elemental sulfur, a by-product of the petrochemical industry, with vinylic comonomers. There is growing interest in polysulfides as novel antimicrobial agents due to the antimicrobial activity of...

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Detalles Bibliográficos
Autores principales: Dop, Romy A., Neill, Daniel R., Hasell, Tom
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7614836/
https://www.ncbi.nlm.nih.gov/pubmed/34784205
http://dx.doi.org/10.1021/acs.biomac.1c01138
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author Dop, Romy A.
Neill, Daniel R.
Hasell, Tom
author_facet Dop, Romy A.
Neill, Daniel R.
Hasell, Tom
author_sort Dop, Romy A.
collection PubMed
description Inverse vulcanization is a bulk polymerization method for synthesizing high sulfur content polymers from elemental sulfur, a by-product of the petrochemical industry, with vinylic comonomers. There is growing interest in polysulfides as novel antimicrobial agents due to the antimicrobial activity of natural polysulfides found in garlic and onions.(1) Herein, we report the antibacterial properties of several inverse vulcanized polymers against Gram-positive Staphylococcus aureus and Gram-negative Pseudomonas aeruginosa, two common causes of nosocomial infection and pathogens identified by the World Health Organization as priorities for antimicrobial development. High sulfur content polymers were synthesized with different divinyl comonomers and at different sulfur:comonomer ratios, to determine the effect of such variables on the antibacterial properties of the resulting materials. Furthermore, polymers were tested for their potential as antibacterial materials at different temperatures. It was found that the test temperature influenced the antibacterial efficacy of the polymers and could be related to the glass transition temperature of the polymer. These findings provide further understanding of the antibacterial properties of inverse vulcanized polymers and show that such polymers have the potential to be used as antibacterial surfaces.
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spelling pubmed-76148362023-07-28 Antibacterial activity of inverse vulcanized polymers Dop, Romy A. Neill, Daniel R. Hasell, Tom Biomacromolecules Article Inverse vulcanization is a bulk polymerization method for synthesizing high sulfur content polymers from elemental sulfur, a by-product of the petrochemical industry, with vinylic comonomers. There is growing interest in polysulfides as novel antimicrobial agents due to the antimicrobial activity of natural polysulfides found in garlic and onions.(1) Herein, we report the antibacterial properties of several inverse vulcanized polymers against Gram-positive Staphylococcus aureus and Gram-negative Pseudomonas aeruginosa, two common causes of nosocomial infection and pathogens identified by the World Health Organization as priorities for antimicrobial development. High sulfur content polymers were synthesized with different divinyl comonomers and at different sulfur:comonomer ratios, to determine the effect of such variables on the antibacterial properties of the resulting materials. Furthermore, polymers were tested for their potential as antibacterial materials at different temperatures. It was found that the test temperature influenced the antibacterial efficacy of the polymers and could be related to the glass transition temperature of the polymer. These findings provide further understanding of the antibacterial properties of inverse vulcanized polymers and show that such polymers have the potential to be used as antibacterial surfaces. 2021-12-13 2021-11-16 /pmc/articles/PMC7614836/ /pubmed/34784205 http://dx.doi.org/10.1021/acs.biomac.1c01138 Text en https://creativecommons.org/licenses/by/4.0/This work is licensed under a BY 4.0 (https://creativecommons.org/licenses/by/4.0/) International license.
spellingShingle Article
Dop, Romy A.
Neill, Daniel R.
Hasell, Tom
Antibacterial activity of inverse vulcanized polymers
title Antibacterial activity of inverse vulcanized polymers
title_full Antibacterial activity of inverse vulcanized polymers
title_fullStr Antibacterial activity of inverse vulcanized polymers
title_full_unstemmed Antibacterial activity of inverse vulcanized polymers
title_short Antibacterial activity of inverse vulcanized polymers
title_sort antibacterial activity of inverse vulcanized polymers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7614836/
https://www.ncbi.nlm.nih.gov/pubmed/34784205
http://dx.doi.org/10.1021/acs.biomac.1c01138
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