Host genetic control of mosquito-borne Flavivirus infections

Flaviviruses are arthropod-borne viruses, several of which represent emerging or re-emerging pathogens responsible for widespread infections with consequences ranging from asymptomatic seroconversion to severe clinical diseases and congenital developmental deficits. This variability is due to multip...

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Autores principales: Manet, Caroline, Roth, Claude, Tawfik, Ahmed, Cantaert, Tineke, Sakuntabhai, Anavaj, Montagutelli, Xavier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7614898/
https://www.ncbi.nlm.nih.gov/pubmed/30167843
http://dx.doi.org/10.1007/s00335-018-9775-2
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author Manet, Caroline
Roth, Claude
Tawfik, Ahmed
Cantaert, Tineke
Sakuntabhai, Anavaj
Montagutelli, Xavier
author_facet Manet, Caroline
Roth, Claude
Tawfik, Ahmed
Cantaert, Tineke
Sakuntabhai, Anavaj
Montagutelli, Xavier
author_sort Manet, Caroline
collection PubMed
description Flaviviruses are arthropod-borne viruses, several of which represent emerging or re-emerging pathogens responsible for widespread infections with consequences ranging from asymptomatic seroconversion to severe clinical diseases and congenital developmental deficits. This variability is due to multiple factors including host genetic determinants the role of which has been investigated in mouse models and human genetic studies. In this review, we provide an overview of the host genes and variants which modify susceptibility or resistance to major mosquito-borne flaviviruses infections in mice and humans.
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spelling pubmed-76148982023-08-09 Host genetic control of mosquito-borne Flavivirus infections Manet, Caroline Roth, Claude Tawfik, Ahmed Cantaert, Tineke Sakuntabhai, Anavaj Montagutelli, Xavier Mamm Genome Article Flaviviruses are arthropod-borne viruses, several of which represent emerging or re-emerging pathogens responsible for widespread infections with consequences ranging from asymptomatic seroconversion to severe clinical diseases and congenital developmental deficits. This variability is due to multiple factors including host genetic determinants the role of which has been investigated in mouse models and human genetic studies. In this review, we provide an overview of the host genes and variants which modify susceptibility or resistance to major mosquito-borne flaviviruses infections in mice and humans. 2018-08-01 2018-08-25 /pmc/articles/PMC7614898/ /pubmed/30167843 http://dx.doi.org/10.1007/s00335-018-9775-2 Text en https://creativecommons.org/licenses/by-nc-sa/4.0/Distributed under a Creative Commons Attribution (https://creativecommons.org/licenses/by-nc-sa/4.0/) - NonCommercial - ShareAlike | 4.0 International License
spellingShingle Article
Manet, Caroline
Roth, Claude
Tawfik, Ahmed
Cantaert, Tineke
Sakuntabhai, Anavaj
Montagutelli, Xavier
Host genetic control of mosquito-borne Flavivirus infections
title Host genetic control of mosquito-borne Flavivirus infections
title_full Host genetic control of mosquito-borne Flavivirus infections
title_fullStr Host genetic control of mosquito-borne Flavivirus infections
title_full_unstemmed Host genetic control of mosquito-borne Flavivirus infections
title_short Host genetic control of mosquito-borne Flavivirus infections
title_sort host genetic control of mosquito-borne flavivirus infections
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7614898/
https://www.ncbi.nlm.nih.gov/pubmed/30167843
http://dx.doi.org/10.1007/s00335-018-9775-2
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