Yolk sac cell atlas reveals multiorgan functions during human early development

The extraembryonic yolk sac (YS) ensures delivery of nutritional support and oxygen to the developing embryo but remains ill-defined in humans. We therefore assembled a comprehensive multiomic reference of human YS from 3-8 post-conception weeks by integrating single-cell protein and gene expression...

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Detalles Bibliográficos
Autores principales: Goh, Issac, Botting, Rachel A., Rose, Antony, Webb, Simone, Engelbert, Justin, Gitton, Yorick, Stephenson, Emily, Londoño, Mariana Quiroga, Mather, Michael, Mende, Nicole, Imaz-Rosshandler, Ivan, Yang, Lu, Horsfall, Dave, Basurto-Lozada, Daniela, Chipampe, Nana-Jane, Rook, Victoria, Lee, Jimmy Tsz Hang, Ton, Mai-Linh, Keitley, Daniel, Mazin, Pavel, Vijayabaskar, M.S., Hannah, Rebecca, Gambardella, Laure, Green, Kile, Ballereau, Stephane, Inoue, Megumi, Tuck, Elizabeth, Lorenzi, Valentina, Kwakwa, Kwasi, Alsinet, Clara, Olabi, Bayanne, Miah, Mohi, Admane, Chloe, Popescu, Dorin-Mirel, Acres, Meghan, Dixon, David, Ness, Thomas, Coulthard, Rowen, Lisgo, Steven, Henderson, Deborah J, Dann, Emma, Suo, Chenqu, Kinston, Sarah J., Park, Jong-eun, Polanski, Krzysztof, Marioni, John, van Dongen, Stijn, Meyer, Kerstin B., de Bruijn, Marella, Palis, James, Behjati, Sam, Laurenti, Elisa, Wilson, Nicola K., Vento-Tormo, Roser, Chédotal, Alain, Bayraktar, Omer, Roberts, Irene, Jardine, Laura, Göttgens, Berthold, Teichmann, Sarah A., Haniffa, Muzlifah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7614978/
https://www.ncbi.nlm.nih.gov/pubmed/37590359
http://dx.doi.org/10.1126/science.add7564
Descripción
Sumario:The extraembryonic yolk sac (YS) ensures delivery of nutritional support and oxygen to the developing embryo but remains ill-defined in humans. We therefore assembled a comprehensive multiomic reference of human YS from 3-8 post-conception weeks by integrating single-cell protein and gene expression data. Beyond its recognized role as a site of hematopoiesis, we highlight roles in metabolism, coagulation, vascular development, and hematopoietic regulation. We reconstructed the emergence and decline of YS hematopoietic stem/progenitor cells from hemogenic endothelium and revealed a YS-specific accelerated route to macrophage production that seeds developing organs. The multiorgan functions of YS are superseded as intraembryonic organs develop, effecting a multifaceted relay of vital functions as pregnancy proceeds.

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