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Multivariate analyses of molecular genetic associations between childhood psychopathology and adult mood disorders and related traits

Ubiquitous associations have been detected between different types of childhood psychopathology and polygenic risk scores based on adult psychiatric disorders and related adult outcomes, indicating that genetic factors partly explain the association between childhood psychopathology and adult outcom...

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Autores principales: Akingbuwa, Wonuola A., Hammerschlag, Anke R., Allegrini, Andrea G., Sallis, Hannah, Kuja-Halkola, Ralf, Rimfeld, Kaili, Lichtenstein, Paul, Lundstrom, Sebastian, Munafò, Marcus R., Plomin, Robert, Nivard, Michel G., Bartels, Meike, Middeldorp, Christel M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7615008/
https://www.ncbi.nlm.nih.gov/pubmed/36380638
http://dx.doi.org/10.1002/ajmg.b.32922
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author Akingbuwa, Wonuola A.
Hammerschlag, Anke R.
Allegrini, Andrea G.
Sallis, Hannah
Kuja-Halkola, Ralf
Rimfeld, Kaili
Lichtenstein, Paul
Lundstrom, Sebastian
Munafò, Marcus R.
Plomin, Robert
Nivard, Michel G.
Bartels, Meike
Middeldorp, Christel M.
author_facet Akingbuwa, Wonuola A.
Hammerschlag, Anke R.
Allegrini, Andrea G.
Sallis, Hannah
Kuja-Halkola, Ralf
Rimfeld, Kaili
Lichtenstein, Paul
Lundstrom, Sebastian
Munafò, Marcus R.
Plomin, Robert
Nivard, Michel G.
Bartels, Meike
Middeldorp, Christel M.
author_sort Akingbuwa, Wonuola A.
collection PubMed
description Ubiquitous associations have been detected between different types of childhood psychopathology and polygenic risk scores based on adult psychiatric disorders and related adult outcomes, indicating that genetic factors partly explain the association between childhood psychopathology and adult outcomes. However, these analyses in general do not take into account the correlations between the adult trait and disorder polygenic risk scores. This study aimed to further clarify the influence of genetic factors on associations between childhood psychopathology and adult outcomes by accounting for these correlations. Using a multivariate multivariable regression, we analyzed associations of childhood attention-deficit/hyperactivity disorder (ADHD), internalizing, and social problems, with polygenic scores (PGS) of adult disorders and traits including major depression, bipolar disorder, subjective well-being, neuroticism, insomnia, educational attainment, and body mass index (BMI), derived for 20,539 children aged 8.5–10.5 years. After correcting for correlations between the adult phenotypes, major depression PGS were associated with all three childhood traits, that is, ADHD, internalizing, and social problems. In addition, BMI PGS were associated with ADHD symptoms and social problems, while neuroticism PGS were only associated with internalizing problems and educational attainment PGS were only associated with ADHD symptoms. PGS of bipolar disorder, subjective well-being, and insomnia were not associated with any childhood traits. Our findings suggest that associations between childhood psychopathology and adult traits like insomnia and subjective well-being may be primarily driven by genetic factors that influence adult major depression. Additionally, specific childhood phenotypes are genetically associated with educational attainment, BMI and neuroticism.
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spelling pubmed-76150082023-09-01 Multivariate analyses of molecular genetic associations between childhood psychopathology and adult mood disorders and related traits Akingbuwa, Wonuola A. Hammerschlag, Anke R. Allegrini, Andrea G. Sallis, Hannah Kuja-Halkola, Ralf Rimfeld, Kaili Lichtenstein, Paul Lundstrom, Sebastian Munafò, Marcus R. Plomin, Robert Nivard, Michel G. Bartels, Meike Middeldorp, Christel M. Am J Med Genet B Neuropsychiatr Genet Article Ubiquitous associations have been detected between different types of childhood psychopathology and polygenic risk scores based on adult psychiatric disorders and related adult outcomes, indicating that genetic factors partly explain the association between childhood psychopathology and adult outcomes. However, these analyses in general do not take into account the correlations between the adult trait and disorder polygenic risk scores. This study aimed to further clarify the influence of genetic factors on associations between childhood psychopathology and adult outcomes by accounting for these correlations. Using a multivariate multivariable regression, we analyzed associations of childhood attention-deficit/hyperactivity disorder (ADHD), internalizing, and social problems, with polygenic scores (PGS) of adult disorders and traits including major depression, bipolar disorder, subjective well-being, neuroticism, insomnia, educational attainment, and body mass index (BMI), derived for 20,539 children aged 8.5–10.5 years. After correcting for correlations between the adult phenotypes, major depression PGS were associated with all three childhood traits, that is, ADHD, internalizing, and social problems. In addition, BMI PGS were associated with ADHD symptoms and social problems, while neuroticism PGS were only associated with internalizing problems and educational attainment PGS were only associated with ADHD symptoms. PGS of bipolar disorder, subjective well-being, and insomnia were not associated with any childhood traits. Our findings suggest that associations between childhood psychopathology and adult traits like insomnia and subjective well-being may be primarily driven by genetic factors that influence adult major depression. Additionally, specific childhood phenotypes are genetically associated with educational attainment, BMI and neuroticism. 2023-01-01 2022-11-15 /pmc/articles/PMC7615008/ /pubmed/36380638 http://dx.doi.org/10.1002/ajmg.b.32922 Text en https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the Creative Commons Attribution (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Article
Akingbuwa, Wonuola A.
Hammerschlag, Anke R.
Allegrini, Andrea G.
Sallis, Hannah
Kuja-Halkola, Ralf
Rimfeld, Kaili
Lichtenstein, Paul
Lundstrom, Sebastian
Munafò, Marcus R.
Plomin, Robert
Nivard, Michel G.
Bartels, Meike
Middeldorp, Christel M.
Multivariate analyses of molecular genetic associations between childhood psychopathology and adult mood disorders and related traits
title Multivariate analyses of molecular genetic associations between childhood psychopathology and adult mood disorders and related traits
title_full Multivariate analyses of molecular genetic associations between childhood psychopathology and adult mood disorders and related traits
title_fullStr Multivariate analyses of molecular genetic associations between childhood psychopathology and adult mood disorders and related traits
title_full_unstemmed Multivariate analyses of molecular genetic associations between childhood psychopathology and adult mood disorders and related traits
title_short Multivariate analyses of molecular genetic associations between childhood psychopathology and adult mood disorders and related traits
title_sort multivariate analyses of molecular genetic associations between childhood psychopathology and adult mood disorders and related traits
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7615008/
https://www.ncbi.nlm.nih.gov/pubmed/36380638
http://dx.doi.org/10.1002/ajmg.b.32922
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