Alzheimer’s genetic risk effects on cerebral blood flow across the lifespan are proximal to gene expression

Cerebrovascular dysregulation such as altered cerebral blood flow (CBF) can be observed in Alzheimer’s disease (AD) and may precede symptom onset. Genome wide association studies show that AD has a polygenic aetiology, providing a tool for studying AD susceptibility across the lifespan. Here, we asc...

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Detalles Bibliográficos
Autores principales: Chandler, Hannah, Wise, Richard, Linden, David, Williams, Julie, Murphy, Kevin, Lancaster, Thomas Matthew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7615143/
https://www.ncbi.nlm.nih.gov/pubmed/36070676
http://dx.doi.org/10.1016/j.neurobiolaging.2022.08.001

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