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Regulation of the length of neuronal primary cilia and its potential effects on signalling

Primary cilia protrude from most vertebrate cell bodies and act as specialized ‘signalling antennae’ that can substantially lengthen or retract in minutes to hours in response to specific stimuli. Here, we review the conditions and mechanisms responsible for regulating primary cilia length (PCL) in...

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Detalles Bibliográficos
Autores principales: Macarelli, Viviana, Leventea, Eleni, Merkle, Florian T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7615206/
https://www.ncbi.nlm.nih.gov/pubmed/37302961
http://dx.doi.org/10.1016/j.tcb.2023.05.005
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author Macarelli, Viviana
Leventea, Eleni
Merkle, Florian T.
author_facet Macarelli, Viviana
Leventea, Eleni
Merkle, Florian T.
author_sort Macarelli, Viviana
collection PubMed
description Primary cilia protrude from most vertebrate cell bodies and act as specialized ‘signalling antennae’ that can substantially lengthen or retract in minutes to hours in response to specific stimuli. Here, we review the conditions and mechanisms responsible for regulating primary cilia length (PCL) in mammalian nonsensory neurons, and propose four models of how they could affect ciliary signalling and alter cell state and suggest experiments to distinguish between them. These models include (i) the passive indicator model, where changes in PCL have no consequence; (ii) the rheostat model, in which a longer cilium enhances signalling; (iii) the local concentration model, where ciliary shortening increases the local protein concentration to facilitate signalling; and (iv) the altered composition model where changes in PCL skew signalling.
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spelling pubmed-76152062023-11-01 Regulation of the length of neuronal primary cilia and its potential effects on signalling Macarelli, Viviana Leventea, Eleni Merkle, Florian T. Trends Cell Biol Article Primary cilia protrude from most vertebrate cell bodies and act as specialized ‘signalling antennae’ that can substantially lengthen or retract in minutes to hours in response to specific stimuli. Here, we review the conditions and mechanisms responsible for regulating primary cilia length (PCL) in mammalian nonsensory neurons, and propose four models of how they could affect ciliary signalling and alter cell state and suggest experiments to distinguish between them. These models include (i) the passive indicator model, where changes in PCL have no consequence; (ii) the rheostat model, in which a longer cilium enhances signalling; (iii) the local concentration model, where ciliary shortening increases the local protein concentration to facilitate signalling; and (iv) the altered composition model where changes in PCL skew signalling. 2023-06-09 2023-06-09 /pmc/articles/PMC7615206/ /pubmed/37302961 http://dx.doi.org/10.1016/j.tcb.2023.05.005 Text en https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ). https://creativecommons.org/licenses/by/4.0/This work is licensed under a CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/) International license.
spellingShingle Article
Macarelli, Viviana
Leventea, Eleni
Merkle, Florian T.
Regulation of the length of neuronal primary cilia and its potential effects on signalling
title Regulation of the length of neuronal primary cilia and its potential effects on signalling
title_full Regulation of the length of neuronal primary cilia and its potential effects on signalling
title_fullStr Regulation of the length of neuronal primary cilia and its potential effects on signalling
title_full_unstemmed Regulation of the length of neuronal primary cilia and its potential effects on signalling
title_short Regulation of the length of neuronal primary cilia and its potential effects on signalling
title_sort regulation of the length of neuronal primary cilia and its potential effects on signalling
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7615206/
https://www.ncbi.nlm.nih.gov/pubmed/37302961
http://dx.doi.org/10.1016/j.tcb.2023.05.005
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