MEG3 activates necroptosis in human neuron xenografts modeling Alzheimer’s disease

Neuronal cell loss is a defining feature of Alzheimer’s disease (AD), but the underlying mechanisms remain unclear. We xenografted human or mouse neurons into the brain of a mouse model of AD. Only human neurons displayed tangles, Gallyas silver staining, granulovacuolar neurodegeneration (GVD), pho...

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Detalles Bibliográficos
Autores principales: Balusu, Sriram, Horré, Katrien, Thrupp, Nicola, Craessaerts, Katleen, Snellinx, An, Serneels, Lutgarde, T’Syen, Dries, Chrysidou, Iordana, Arranz, Amaia M., Sierksma, Annerieke, Simrén, Joel, Karikari, Thomas K., Zetterberg, Henrik, Chen, Wei-Ting, Thal, Dietmar Rudolf, Salta, Evgenia, Fiers, Mark, De Strooper, Bart
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7615236/
https://www.ncbi.nlm.nih.gov/pubmed/37708272
http://dx.doi.org/10.1126/science.abp9556

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7615236/
https://www.ncbi.nlm.nih.gov/pubmed/37708272
http://dx.doi.org/10.1126/science.abp9556

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