Single-cell transcriptomic atlas-guided development of CAR-T cells for the treatment of acute myeloid leukemia

Chimeric-antigen receptor (CAR) T cells have emerged as a powerful treatment option for patients with B cell malignancies but have yet to achieve success in treating acute myeloid leukemia (AML) due to a lack of safe targets. Here, we leveraged an atlas of publicly available RNA sequencing data of o...

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Detalles Bibliográficos
Autores principales: Gottschlich, Adrian, Thomas, Moritz, Grünmeier, Ruth, Lesch, Stefanie, Rohrbacher, Lisa, Igl, Veronika, Briukhovetska, Daria, Benmebarek, Mohamed-Reda, Vick, Binje, Dede, Sertac, Müller, Katharina, Xu, Tao, Dhoqina, Dario, Märkl, Florian, Robinson, Sophie, Sendelhofert, Andrea, Schulz, Heiko, Umut, Öykü, Kavaka, Vladyslav, Tsiverioti, Christina Angeliki, Carlini, Emanuele, Nandi, Sayantan, Strzalkowski, Thaddäus, Lorenzini, Theo, Stock, Sophia, Müller, Philipp Jie, Dörr, Janina, Seifert, Matthias, Cadilha, Bruno L., Brabenec, Ruben, Röder, Natalie, Rataj, Felicitas, Nüesch, Manuel, Modemann, Franziska, Wellbrock, Jasmin, Fiedler, Walter, Kellner, Christian, Beltrán, Eduardo, Herold, Tobias, Paquet, Dominik, Jeremias, Irmela, von Baumgarten, Louisa, Endres, Stefan, Subklewe, Marion, Marr, Carsten, Kobold, Sebastian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7615296/
https://www.ncbi.nlm.nih.gov/pubmed/36914885
http://dx.doi.org/10.1038/s41587-023-01684-0

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