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Transgenic CD8αβ co-receptor rescues endogenous TCR function in TCR-transgenic virus-specific T cells

BACKGROUND: Genetically engineered virus-specific T cells (VSTs) are a platform for adoptive cell therapy after allogeneic hematopoietic stem cell transplantation. However, redirection to a tumor-associated antigen by the introduction of a transgenic T-cell receptor (TCR) reduces anti-viral activity...

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Detalles Bibliográficos
Autores principales:	Bajwa, Gagan, Lanz, Inès, Cardenas, Mara, Brenner, Malcolm K, Arber, Caroline
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2020
Materias:	Immune Cell Therapies and Immune Cell Engineering
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7640589/ https://www.ncbi.nlm.nih.gov/pubmed/33148692 http://dx.doi.org/10.1136/jitc-2020-001487

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