APOE2: protective mechanism and therapeutic implications for Alzheimer’s disease

Investigations of apolipoprotein E (APOE) gene, the major genetic risk modifier for Alzheimer’s disease (AD), have yielded significant insights into the pathogenic mechanism. Among the three common coding variants, APOE*ε4 increases, whereas APOE*ε2 decreases the risk of late-onset AD compared with...

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Detalles Bibliográficos
Autores principales: Li, Zonghua, Shue, Francis, Zhao, Na, Shinohara, Mitsuru, Bu, Guojun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7640652/
https://www.ncbi.nlm.nih.gov/pubmed/33148290
http://dx.doi.org/10.1186/s13024-020-00413-4

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