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BRD4 and PIN1 gene polymorphisms are associated with high pulse pressure risk in a southeastern Chinese population

BACKGROUND: BRD4 and PIN1 have been described to be involved in inflammation and vascular endothelial cell dysfunction, which in turn may increase pulse pressure. HYPOTHESIS: Genetic mutations within the BRD4 and PIN1 genes could affect the risk of high pulse pressure. METHODS: A total of four singl...

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Autores principales: Qiu, Jin-jia, Yang, Rui-zhi, Tang, Yi-jie, Lin, Ying-yi, Xu, Hao-jie, Zhang, Na, Liang, Min, Cai, Hong-da, Zeng, Kai, Wu, Xiao-dan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7640679/
https://www.ncbi.nlm.nih.gov/pubmed/33148187
http://dx.doi.org/10.1186/s12872-020-01757-x
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author Qiu, Jin-jia
Yang, Rui-zhi
Tang, Yi-jie
Lin, Ying-yi
Xu, Hao-jie
Zhang, Na
Liang, Min
Cai, Hong-da
Zeng, Kai
Wu, Xiao-dan
author_facet Qiu, Jin-jia
Yang, Rui-zhi
Tang, Yi-jie
Lin, Ying-yi
Xu, Hao-jie
Zhang, Na
Liang, Min
Cai, Hong-da
Zeng, Kai
Wu, Xiao-dan
author_sort Qiu, Jin-jia
collection PubMed
description BACKGROUND: BRD4 and PIN1 have been described to be involved in inflammation and vascular endothelial cell dysfunction, which in turn may increase pulse pressure. HYPOTHESIS: Genetic mutations within the BRD4 and PIN1 genes could affect the risk of high pulse pressure. METHODS: A total of four single nucleotide polymorphisms (SNPs) (BRD4: rs4808278; PIN1: rs2233678, rs2287838, and rs2233682) were genotyped in a cohort of 666 hypertensive patients and 232 normotensive controls with Chinese Han origin. Generalized multifactor dimensionality reduction (GMDR) was used to screen the best interaction combination among the four SNPs within the BRD4 and PIN1 genes and diabetes. Logistic regression analysis was performed to calculate the odds ratio (ORs) (95% confidence interval (CI)) for the association between the four SNPs. RESULTS: Adjusted for age, weight, waist circumference, drinking, smoking, hypertension, and diabetes, high pulse pressure risk was significantly higher for carriers with the rs4808278-TT genotype in BRD4 than those with wild genotypes (OR: 0.400, 95% CI: 0.217–0.737, P* < 0.05). However, we did not find any significant association of rs2233678, rs2287838, and rs2233682 in PIN1 with high pulse pressure susceptibility after covariate adjustment. GMDR analysis indicated a significant three-locus model (P = 0.0107) involving rs4808278, rs2233678, and diabetes, the cross-validation consistency of the three-locus models was 9/10, and the testing accuracy was 57.47%. CONCLUSIONS: Genetic mutations within BRD4 (rs4808278) could affect the susceptibility to high pulse pressure in a southeastern Chinese population.
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spelling pubmed-76406792020-11-04 BRD4 and PIN1 gene polymorphisms are associated with high pulse pressure risk in a southeastern Chinese population Qiu, Jin-jia Yang, Rui-zhi Tang, Yi-jie Lin, Ying-yi Xu, Hao-jie Zhang, Na Liang, Min Cai, Hong-da Zeng, Kai Wu, Xiao-dan BMC Cardiovasc Disord Research Article BACKGROUND: BRD4 and PIN1 have been described to be involved in inflammation and vascular endothelial cell dysfunction, which in turn may increase pulse pressure. HYPOTHESIS: Genetic mutations within the BRD4 and PIN1 genes could affect the risk of high pulse pressure. METHODS: A total of four single nucleotide polymorphisms (SNPs) (BRD4: rs4808278; PIN1: rs2233678, rs2287838, and rs2233682) were genotyped in a cohort of 666 hypertensive patients and 232 normotensive controls with Chinese Han origin. Generalized multifactor dimensionality reduction (GMDR) was used to screen the best interaction combination among the four SNPs within the BRD4 and PIN1 genes and diabetes. Logistic regression analysis was performed to calculate the odds ratio (ORs) (95% confidence interval (CI)) for the association between the four SNPs. RESULTS: Adjusted for age, weight, waist circumference, drinking, smoking, hypertension, and diabetes, high pulse pressure risk was significantly higher for carriers with the rs4808278-TT genotype in BRD4 than those with wild genotypes (OR: 0.400, 95% CI: 0.217–0.737, P* < 0.05). However, we did not find any significant association of rs2233678, rs2287838, and rs2233682 in PIN1 with high pulse pressure susceptibility after covariate adjustment. GMDR analysis indicated a significant three-locus model (P = 0.0107) involving rs4808278, rs2233678, and diabetes, the cross-validation consistency of the three-locus models was 9/10, and the testing accuracy was 57.47%. CONCLUSIONS: Genetic mutations within BRD4 (rs4808278) could affect the susceptibility to high pulse pressure in a southeastern Chinese population. BioMed Central 2020-11-04 /pmc/articles/PMC7640679/ /pubmed/33148187 http://dx.doi.org/10.1186/s12872-020-01757-x Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Qiu, Jin-jia
Yang, Rui-zhi
Tang, Yi-jie
Lin, Ying-yi
Xu, Hao-jie
Zhang, Na
Liang, Min
Cai, Hong-da
Zeng, Kai
Wu, Xiao-dan
BRD4 and PIN1 gene polymorphisms are associated with high pulse pressure risk in a southeastern Chinese population
title BRD4 and PIN1 gene polymorphisms are associated with high pulse pressure risk in a southeastern Chinese population
title_full BRD4 and PIN1 gene polymorphisms are associated with high pulse pressure risk in a southeastern Chinese population
title_fullStr BRD4 and PIN1 gene polymorphisms are associated with high pulse pressure risk in a southeastern Chinese population
title_full_unstemmed BRD4 and PIN1 gene polymorphisms are associated with high pulse pressure risk in a southeastern Chinese population
title_short BRD4 and PIN1 gene polymorphisms are associated with high pulse pressure risk in a southeastern Chinese population
title_sort brd4 and pin1 gene polymorphisms are associated with high pulse pressure risk in a southeastern chinese population
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7640679/
https://www.ncbi.nlm.nih.gov/pubmed/33148187
http://dx.doi.org/10.1186/s12872-020-01757-x
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