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LncRNA SNHG3, a potential oncogene in human cancers
Long noncoding RNAs (lncRNAs) are composed of > 200 nucleotides; they lack the ability to encode proteins but play important roles in a variety of human tumors. A large number of studies have shown that dysregulated expression of lncRNAs is related to tumor oncogenesis and progression. Emerging e...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7640707/ https://www.ncbi.nlm.nih.gov/pubmed/33292213 http://dx.doi.org/10.1186/s12935-020-01608-x |
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author | Xu, Bin Mei, Jie Ji, Wei Bian, Zheng Jiao, Jiantong Sun, Jun Shao, Junfei |
author_facet | Xu, Bin Mei, Jie Ji, Wei Bian, Zheng Jiao, Jiantong Sun, Jun Shao, Junfei |
author_sort | Xu, Bin |
collection | PubMed |
description | Long noncoding RNAs (lncRNAs) are composed of > 200 nucleotides; they lack the ability to encode proteins but play important roles in a variety of human tumors. A large number of studies have shown that dysregulated expression of lncRNAs is related to tumor oncogenesis and progression. Emerging evidence shows that SNHG3 is a novel oncogenic lncRNA that is abnormally expressed in various tumors, including osteosarcoma, liver cancer, lung cancer, etc. SNHG3 primarily competes as a competitive endogenous RNA (ceRNA) that targets tumor suppressor microRNAs (miRNAs) and ceRNA mechanisms that regulate biological processes of tumors. In addition, abnormal expression of SNHG3 is significantly correlated with patient clinical features. Upregulation of SNHG3 contributes to biological functions, including tumor cell proliferation, migration, invasion and EMT. Therefore, SNHG3 may represent a potential diagnostic and prognostic biomarker, as well as a novel therapeutic target. |
format | Online Article Text |
id | pubmed-7640707 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-76407072020-11-05 LncRNA SNHG3, a potential oncogene in human cancers Xu, Bin Mei, Jie Ji, Wei Bian, Zheng Jiao, Jiantong Sun, Jun Shao, Junfei Cancer Cell Int Review Long noncoding RNAs (lncRNAs) are composed of > 200 nucleotides; they lack the ability to encode proteins but play important roles in a variety of human tumors. A large number of studies have shown that dysregulated expression of lncRNAs is related to tumor oncogenesis and progression. Emerging evidence shows that SNHG3 is a novel oncogenic lncRNA that is abnormally expressed in various tumors, including osteosarcoma, liver cancer, lung cancer, etc. SNHG3 primarily competes as a competitive endogenous RNA (ceRNA) that targets tumor suppressor microRNAs (miRNAs) and ceRNA mechanisms that regulate biological processes of tumors. In addition, abnormal expression of SNHG3 is significantly correlated with patient clinical features. Upregulation of SNHG3 contributes to biological functions, including tumor cell proliferation, migration, invasion and EMT. Therefore, SNHG3 may represent a potential diagnostic and prognostic biomarker, as well as a novel therapeutic target. BioMed Central 2020-11-04 /pmc/articles/PMC7640707/ /pubmed/33292213 http://dx.doi.org/10.1186/s12935-020-01608-x Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Xu, Bin Mei, Jie Ji, Wei Bian, Zheng Jiao, Jiantong Sun, Jun Shao, Junfei LncRNA SNHG3, a potential oncogene in human cancers |
title | LncRNA SNHG3, a potential oncogene in human cancers |
title_full | LncRNA SNHG3, a potential oncogene in human cancers |
title_fullStr | LncRNA SNHG3, a potential oncogene in human cancers |
title_full_unstemmed | LncRNA SNHG3, a potential oncogene in human cancers |
title_short | LncRNA SNHG3, a potential oncogene in human cancers |
title_sort | lncrna snhg3, a potential oncogene in human cancers |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7640707/ https://www.ncbi.nlm.nih.gov/pubmed/33292213 http://dx.doi.org/10.1186/s12935-020-01608-x |
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