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Ocular surface characterization after allogeneic stem cell transplantation: A prospective study in a referral center

PURPOSE: To characterize anatomical and functional changes in the ocular surface after hematopoietic stem cell transplantation. METHODS: Three groups of patients were included in the study. Group 1: patients who had undergone allogeneic hematopoietic stem cell transplantation (HSCT) (n = 26). Group...

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Detalles Bibliográficos
Autores principales: Alba-Linero, Carmen, Rodriguez Calvo de Mora, Marina, Lavado Valenzuela, Rocío, Pascual Cascón, María Jesús, Martín Cerezo, Alejandra Rosario, Álvarez Pérez, Martina, Recio, Luis Vicioso, Jerez Aragonés, José Manuel, García Campos, José Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7640859/
https://www.ncbi.nlm.nih.gov/pubmed/32709775
http://dx.doi.org/10.4103/ijo.IJO_1865_19
Descripción
Sumario:PURPOSE: To characterize anatomical and functional changes in the ocular surface after hematopoietic stem cell transplantation. METHODS: Three groups of patients were included in the study. Group 1: patients who had undergone allogeneic hematopoietic stem cell transplantation (HSCT) (n = 26). Group 2: patients who developed chronic graft versus host disease (GvHD) after HSCT (n = 14). Group 3: healthy subjects (n = 20). A complete ophthalmological examination was undertaken in all subjects, including Schirmer's test, TBUT (break-up-time) test, Oxford scale, OSDI test, corneal tomography, and conjunctival CD8+ lymphocyte detection. RESULTS: In Branch 1 (comparative analysis before and after HSCT in Group 1), statistically significant differences were found in the following variables: best-corrected visual acuity (BCVA) OD (P = 0.08), OSDI test (P = 0.003), TBUT OU (OD P = 0, OS P = 0.0003), Oxford test OU (OD P = 0.01, OS P = 0.0049), and CD8+ lymphocytes OU (OD P = 0.003, OS P = 0.01). In Branch 2 (comparative analysis between Group 2 and 3), the variables with statistically significant differences (P < 0.001) in OU were: BCVA, OSDI test, Schirmer's test OU, TBUT test, Oxford test, and CD8+ lymphocytes. Finally, in Branch 3 (comparative analysis between Group 1 after HSCT and Group 2), statistically significant differences (P < 0.001) were found OU: in OSDI test, Schirmer's test, and Oxford test OU; and with P < 0.005 in TBUT test OU. CONCLUSION: In our study, statistically significant changes were observed in the OSDI test, TBUT test, Oxford Scale, and the detection of CD8+ lymphocytes in patients who underwent HSCT. Differences were more significant in those patients who had developed GvHD after HSCT compared to those without GvHD.