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Peripheral Microangiopathy in Patients with Precapillary Pulmonary Hypertension: Correlation with Cardiac Function and Patients’ Functional Capacity. Study Design and Rationale

Pulmonary hypertension (PH) is a rare, heterogenous clinical entity characterised by a progressive remodelling of pulmonary arterioles, which leads to obstructive pulmonary arteriopathy, increased pulmonary vascular resistance, and eventually, right heart failure. Inflammation, endothelial dysfuncti...

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Autores principales: Arvanitaki, Alexandra, Giannakoulas, George, Triantafyllidou, Eva, Karvounis, Haralambos, Dimitroulas, Theodoros
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Mediterranean Journal of Rheumatology (MJR) 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7641020/
https://www.ncbi.nlm.nih.gov/pubmed/33163874
http://dx.doi.org/10.31138/mjr.31.3.369
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author Arvanitaki, Alexandra
Giannakoulas, George
Triantafyllidou, Eva
Karvounis, Haralambos
Dimitroulas, Theodoros
author_facet Arvanitaki, Alexandra
Giannakoulas, George
Triantafyllidou, Eva
Karvounis, Haralambos
Dimitroulas, Theodoros
author_sort Arvanitaki, Alexandra
collection PubMed
description Pulmonary hypertension (PH) is a rare, heterogenous clinical entity characterised by a progressive remodelling of pulmonary arterioles, which leads to obstructive pulmonary arteriopathy, increased pulmonary vascular resistance, and eventually, right heart failure. Inflammation, endothelial dysfunction, and microvascular changes of the pulmonary vasculature constitute the hallmarks of pulmonary arterial hypertension (PAH), explaining much of the pathophysiology and clinical manifestations of the disease. Besides pulmonary vasculature, a systemic component of endothelial dysfunction and microcirculation may be involved in PAH, affecting different vascular beds. Nailfold videocapillaroscopy (NVC) is an established method for the assessment of the microvasculature with clinical implications in the diagnostic assessment of individuals with Raynaud syndrome and systemic sclerosis (SSc). Nowadays, growing amounts of evidence suggest that NVC changes in SSc are correlated with other vascular complications such as PAH, supporting a potential link between peripheral and internal organ vasculopathy. The purpose of the current prospective observational study is to explore: 1. the presence of peripheral microangiopathy in precapillary PH using NVC, 2. possible NVC differences among PH subgroups, 3. a potential relationship between NVC morphological abnormalities and clinical, functional, biochemical, echocardiographic and hemodynamic markers of cardiac dysfunction in precapillary PH.
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spelling pubmed-76410202020-11-06 Peripheral Microangiopathy in Patients with Precapillary Pulmonary Hypertension: Correlation with Cardiac Function and Patients’ Functional Capacity. Study Design and Rationale Arvanitaki, Alexandra Giannakoulas, George Triantafyllidou, Eva Karvounis, Haralambos Dimitroulas, Theodoros Mediterr J Rheumatol Research Protocol Pulmonary hypertension (PH) is a rare, heterogenous clinical entity characterised by a progressive remodelling of pulmonary arterioles, which leads to obstructive pulmonary arteriopathy, increased pulmonary vascular resistance, and eventually, right heart failure. Inflammation, endothelial dysfunction, and microvascular changes of the pulmonary vasculature constitute the hallmarks of pulmonary arterial hypertension (PAH), explaining much of the pathophysiology and clinical manifestations of the disease. Besides pulmonary vasculature, a systemic component of endothelial dysfunction and microcirculation may be involved in PAH, affecting different vascular beds. Nailfold videocapillaroscopy (NVC) is an established method for the assessment of the microvasculature with clinical implications in the diagnostic assessment of individuals with Raynaud syndrome and systemic sclerosis (SSc). Nowadays, growing amounts of evidence suggest that NVC changes in SSc are correlated with other vascular complications such as PAH, supporting a potential link between peripheral and internal organ vasculopathy. The purpose of the current prospective observational study is to explore: 1. the presence of peripheral microangiopathy in precapillary PH using NVC, 2. possible NVC differences among PH subgroups, 3. a potential relationship between NVC morphological abnormalities and clinical, functional, biochemical, echocardiographic and hemodynamic markers of cardiac dysfunction in precapillary PH. The Mediterranean Journal of Rheumatology (MJR) 2020-06-10 /pmc/articles/PMC7641020/ /pubmed/33163874 http://dx.doi.org/10.31138/mjr.31.3.369 Text en © 2020 The Mediterranean Journal of Rheumatology (MJR) http://creativecommons.org/licenses/by/4.0/ This work is licensed under and Creative Commons Attribution-NonCommercial 4.0 International License.
spellingShingle Research Protocol
Arvanitaki, Alexandra
Giannakoulas, George
Triantafyllidou, Eva
Karvounis, Haralambos
Dimitroulas, Theodoros
Peripheral Microangiopathy in Patients with Precapillary Pulmonary Hypertension: Correlation with Cardiac Function and Patients’ Functional Capacity. Study Design and Rationale
title Peripheral Microangiopathy in Patients with Precapillary Pulmonary Hypertension: Correlation with Cardiac Function and Patients’ Functional Capacity. Study Design and Rationale
title_full Peripheral Microangiopathy in Patients with Precapillary Pulmonary Hypertension: Correlation with Cardiac Function and Patients’ Functional Capacity. Study Design and Rationale
title_fullStr Peripheral Microangiopathy in Patients with Precapillary Pulmonary Hypertension: Correlation with Cardiac Function and Patients’ Functional Capacity. Study Design and Rationale
title_full_unstemmed Peripheral Microangiopathy in Patients with Precapillary Pulmonary Hypertension: Correlation with Cardiac Function and Patients’ Functional Capacity. Study Design and Rationale
title_short Peripheral Microangiopathy in Patients with Precapillary Pulmonary Hypertension: Correlation with Cardiac Function and Patients’ Functional Capacity. Study Design and Rationale
title_sort peripheral microangiopathy in patients with precapillary pulmonary hypertension: correlation with cardiac function and patients’ functional capacity. study design and rationale
topic Research Protocol
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7641020/
https://www.ncbi.nlm.nih.gov/pubmed/33163874
http://dx.doi.org/10.31138/mjr.31.3.369
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