PAI-1-Dependent Inactivation of SMAD4-Modulated Junction and Adhesion Complex in Obese Endometrial Cancer

While plasminogen activator inhibitor-1 (PAI-1) is known to potentiate cellular migration via proteolytic regulation, this adipokine is implicated as an oncogenic ligand in the tumor microenvironment. To understand the underlying paracrine mechanism, here, we conduct transcriptomic analysis of 1,898...

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Detalles Bibliográficos
Autores principales: Lin, Li-Ling, Kost, Edward R., Lin, Chun-Lin, Valente, Philip, Wang, Chiou-Miin, Kolonin, Mikhail G., Daquinag, Alexes C., Tan, Xi, Lucio, Nicholas, Hung, Chia-Nung, Wang, Chen-Pin, Kirma, Nameer B., Huang, Tim H.-M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7641039/
https://www.ncbi.nlm.nih.gov/pubmed/33053339
http://dx.doi.org/10.1016/j.celrep.2020.108253

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