Atomic Structures of Closed and Open Influenza B M2 Proton Channel Reveal the Conduction Mechanism

The influenza B M2 (BM2) proton channel is activated by acidic pH to mediate virus uncoating. Unlike influenza A M2 (AM2), which conducts protons with strong inward rectification, BM2 conducts protons both inward and outward. Here we report 1.4- and 1.5-angstrom solid-state NMR structures of the tra...

Descripción completa

Detalles Bibliográficos
Autores principales: Mandala, Venkata S., Loftis, Alexander R., Shcherbakov, Alexander A., Pentelute, Bradley L., Hong, Mei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7641042/
https://www.ncbi.nlm.nih.gov/pubmed/32015551
http://dx.doi.org/10.1038/s41594-019-0371-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7641042/
https://www.ncbi.nlm.nih.gov/pubmed/32015551
http://dx.doi.org/10.1038/s41594-019-0371-2

Ejemplares similares