A cell-based bioluminescence assay reveals dose-dependent and contextual repression of AP-1-driven gene expression by BACH2

Whereas effector CD4(+) and CD8(+) T cells promote immune activation and can drive clearance of infections and cancer, CD4(+) regulatory T (T(reg)) cells suppress their function, contributing to both immune homeostasis and cancer immunosuppression. The transcription factor BACH2 functions as a perva...

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Detalles Bibliográficos
Autores principales: Vardaka, Panagiota, Lozano, Teresa, Bot, Christopher, Ellery, Jonathan, Whiteside, Sarah K., Imianowski, Charlotte J., Farrow, Stuart, Walker, Simon, Okkenhaug, Hanneke, Yang, Jie, Okkenhaug, Klaus, Kuo, Paula, Roychoudhuri, Rahul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7641119/
https://www.ncbi.nlm.nih.gov/pubmed/33144667
http://dx.doi.org/10.1038/s41598-020-75732-z

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