Structure of the PCBP2/stem–loop IV complex underlying translation initiation mediated by the poliovirus type I IRES

The poliovirus type I IRES is able to recruit ribosomal machinery only in the presence of host factor PCBP2 that binds to stem–loop IV of the IRES. When PCBP2 is cleaved in its linker region by viral proteinase 3CD, translation initiation ceases allowing the next stage of replication to commence. He...

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Detalles Bibliográficos
Autores principales: Beckham, Simone A, Matak, Mehdi Y, Belousoff, Matthew J, Venugopal, Hariprasad, Shah, Neelam, Vankadari, Naveen, Elmlund, Hans, Nguyen, Joseph H C, Semler, Bert L, Wilce, Matthew C J, Wilce, Jacqueline A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7641305/
https://www.ncbi.nlm.nih.gov/pubmed/32556302
http://dx.doi.org/10.1093/nar/gkaa519

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