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Clinical outcomes of coronavirus disease 2019 in patients with pre-existing liver diseases: A multicenter study in South Korea
BACKGROUND/AIMS: Although coronavirus disease 2019 (COVID-19) has spread rapidly worldwide, the implication of pre-existing liver disease on the outcome of COVID-19 remains unresolved. METHODS: A total of 1,005 patients who were admitted to five tertiary hospitals in South Korea with laboratory-conf...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Association for the Study of the Liver
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7641571/ https://www.ncbi.nlm.nih.gov/pubmed/33053932 http://dx.doi.org/10.3350/cmh.2020.0126 |
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author | Lee, Yu Rim Kang, Min Kyu Song, Jeong Eun Kim, Hyun Jung Kweon, Young Oh Tak, Won Young Jang, Se Young Park, Jung Gil Lee, Changhyeong Hwang, Jae Seok Jang, Byoung Kuk Suh, Jeong Ill Chung, Woo Jin Kim, Byung Seok Park, Soo Young |
author_facet | Lee, Yu Rim Kang, Min Kyu Song, Jeong Eun Kim, Hyun Jung Kweon, Young Oh Tak, Won Young Jang, Se Young Park, Jung Gil Lee, Changhyeong Hwang, Jae Seok Jang, Byoung Kuk Suh, Jeong Ill Chung, Woo Jin Kim, Byung Seok Park, Soo Young |
author_sort | Lee, Yu Rim |
collection | PubMed |
description | BACKGROUND/AIMS: Although coronavirus disease 2019 (COVID-19) has spread rapidly worldwide, the implication of pre-existing liver disease on the outcome of COVID-19 remains unresolved. METHODS: A total of 1,005 patients who were admitted to five tertiary hospitals in South Korea with laboratory-confirmed COVID-19 were included in this study. Clinical outcomes in COVID-19 patients with coexisting liver disease as well as the predictors of disease severity and mortality of COVID-19 were assessed. RESULTS: Of the 47 patients (4.7%) who had liver-related comorbidities, 14 patients (1.4%) had liver cirrhosis. Liver cirrhosis was more common in COVID-19 patients with severe pneumonia than in those with non-severe pneumonia (4.5% vs. 0.9%, P=0.006). Compared to patients without liver cirrhosis, a higher proportion of patients with liver cirrhosis required oxygen therapy; were admitted to the intensive care unit; had septic shock, acute respiratory distress syndrome, or acute kidney injury; and died (P<0.05). The overall survival rate was significantly lower in patients with liver cirrhosis than in those without liver cirrhosis (log-rank test, P=0.003). Along with old age and diabetes, the presence of liver cirrhosis was found to be an independent predictor of severe disease (odds ratio, 4.52; 95% confidence interval [CI], 1.20–17.02;P=0.026) and death (hazard ratio, 2.86; 95% CI, 1.04–9.30; P=0.042) in COVID-19 patients. CONCLUSIONS: This study suggests liver cirrhosis is a significant risk factor for COVID-19. Stronger personal protection and more intensive treatment for COVID-19 are recommended in these patients. |
format | Online Article Text |
id | pubmed-7641571 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | The Korean Association for the Study of the Liver |
record_format | MEDLINE/PubMed |
spelling | pubmed-76415712020-11-13 Clinical outcomes of coronavirus disease 2019 in patients with pre-existing liver diseases: A multicenter study in South Korea Lee, Yu Rim Kang, Min Kyu Song, Jeong Eun Kim, Hyun Jung Kweon, Young Oh Tak, Won Young Jang, Se Young Park, Jung Gil Lee, Changhyeong Hwang, Jae Seok Jang, Byoung Kuk Suh, Jeong Ill Chung, Woo Jin Kim, Byung Seok Park, Soo Young Clin Mol Hepatol Original Article BACKGROUND/AIMS: Although coronavirus disease 2019 (COVID-19) has spread rapidly worldwide, the implication of pre-existing liver disease on the outcome of COVID-19 remains unresolved. METHODS: A total of 1,005 patients who were admitted to five tertiary hospitals in South Korea with laboratory-confirmed COVID-19 were included in this study. Clinical outcomes in COVID-19 patients with coexisting liver disease as well as the predictors of disease severity and mortality of COVID-19 were assessed. RESULTS: Of the 47 patients (4.7%) who had liver-related comorbidities, 14 patients (1.4%) had liver cirrhosis. Liver cirrhosis was more common in COVID-19 patients with severe pneumonia than in those with non-severe pneumonia (4.5% vs. 0.9%, P=0.006). Compared to patients without liver cirrhosis, a higher proportion of patients with liver cirrhosis required oxygen therapy; were admitted to the intensive care unit; had septic shock, acute respiratory distress syndrome, or acute kidney injury; and died (P<0.05). The overall survival rate was significantly lower in patients with liver cirrhosis than in those without liver cirrhosis (log-rank test, P=0.003). Along with old age and diabetes, the presence of liver cirrhosis was found to be an independent predictor of severe disease (odds ratio, 4.52; 95% confidence interval [CI], 1.20–17.02;P=0.026) and death (hazard ratio, 2.86; 95% CI, 1.04–9.30; P=0.042) in COVID-19 patients. CONCLUSIONS: This study suggests liver cirrhosis is a significant risk factor for COVID-19. Stronger personal protection and more intensive treatment for COVID-19 are recommended in these patients. The Korean Association for the Study of the Liver 2020-10 2020-10-01 /pmc/articles/PMC7641571/ /pubmed/33053932 http://dx.doi.org/10.3350/cmh.2020.0126 Text en Copyright © 2020 by The Korean Association for the Study of the Liver This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Lee, Yu Rim Kang, Min Kyu Song, Jeong Eun Kim, Hyun Jung Kweon, Young Oh Tak, Won Young Jang, Se Young Park, Jung Gil Lee, Changhyeong Hwang, Jae Seok Jang, Byoung Kuk Suh, Jeong Ill Chung, Woo Jin Kim, Byung Seok Park, Soo Young Clinical outcomes of coronavirus disease 2019 in patients with pre-existing liver diseases: A multicenter study in South Korea |
title | Clinical outcomes of coronavirus disease 2019 in patients with pre-existing liver diseases: A multicenter study in South Korea |
title_full | Clinical outcomes of coronavirus disease 2019 in patients with pre-existing liver diseases: A multicenter study in South Korea |
title_fullStr | Clinical outcomes of coronavirus disease 2019 in patients with pre-existing liver diseases: A multicenter study in South Korea |
title_full_unstemmed | Clinical outcomes of coronavirus disease 2019 in patients with pre-existing liver diseases: A multicenter study in South Korea |
title_short | Clinical outcomes of coronavirus disease 2019 in patients with pre-existing liver diseases: A multicenter study in South Korea |
title_sort | clinical outcomes of coronavirus disease 2019 in patients with pre-existing liver diseases: a multicenter study in south korea |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7641571/ https://www.ncbi.nlm.nih.gov/pubmed/33053932 http://dx.doi.org/10.3350/cmh.2020.0126 |
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