Cargando…
The Impact of Milk and Its Components on Epigenetic Programming of Immune Function in Early Life and Beyond: Implications for Allergy and Asthma
Specific and adequate nutrition during pregnancy and early life is an important factor in avoiding non-communicable diseases such as obesity, type 2 diabetes, cardiovascular disease, cancers, and chronic allergic diseases. Although epidemiologic and experimental studies have shown that nutrition is...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7641638/ https://www.ncbi.nlm.nih.gov/pubmed/33193294 http://dx.doi.org/10.3389/fimmu.2020.02141 |
_version_ | 1783605960349057024 |
---|---|
author | van Esch, Betty C. A. M. Porbahaie, Mojtaba Abbring, Suzanne Garssen, Johan Potaczek, Daniel P. Savelkoul, Huub F. J. van Neerven, R. J. Joost |
author_facet | van Esch, Betty C. A. M. Porbahaie, Mojtaba Abbring, Suzanne Garssen, Johan Potaczek, Daniel P. Savelkoul, Huub F. J. van Neerven, R. J. Joost |
author_sort | van Esch, Betty C. A. M. |
collection | PubMed |
description | Specific and adequate nutrition during pregnancy and early life is an important factor in avoiding non-communicable diseases such as obesity, type 2 diabetes, cardiovascular disease, cancers, and chronic allergic diseases. Although epidemiologic and experimental studies have shown that nutrition is important at all stages of life, it is especially important in prenatal and the first few years of life. During the last decade, there has been a growing interest in the potential role of epigenetic mechanisms in the increasing health problems associated with allergic disease. Epigenetics involves several mechanisms including DNA methylation, histone modifications, and microRNAs which can modify the expression of genes. In this study, we focus on the effects of maternal nutrition during pregnancy, the effects of the bioactive components in human and bovine milk, and the environmental factors that can affect early life (i.e., farming, milk processing, and bacterial exposure), and which contribute to the epigenetic mechanisms underlying the persistent programming of immune functions and allergic diseases. This knowledge will help to improve approaches to nutrition in early life and help prevent allergies in the future. |
format | Online Article Text |
id | pubmed-7641638 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-76416382020-11-13 The Impact of Milk and Its Components on Epigenetic Programming of Immune Function in Early Life and Beyond: Implications for Allergy and Asthma van Esch, Betty C. A. M. Porbahaie, Mojtaba Abbring, Suzanne Garssen, Johan Potaczek, Daniel P. Savelkoul, Huub F. J. van Neerven, R. J. Joost Front Immunol Immunology Specific and adequate nutrition during pregnancy and early life is an important factor in avoiding non-communicable diseases such as obesity, type 2 diabetes, cardiovascular disease, cancers, and chronic allergic diseases. Although epidemiologic and experimental studies have shown that nutrition is important at all stages of life, it is especially important in prenatal and the first few years of life. During the last decade, there has been a growing interest in the potential role of epigenetic mechanisms in the increasing health problems associated with allergic disease. Epigenetics involves several mechanisms including DNA methylation, histone modifications, and microRNAs which can modify the expression of genes. In this study, we focus on the effects of maternal nutrition during pregnancy, the effects of the bioactive components in human and bovine milk, and the environmental factors that can affect early life (i.e., farming, milk processing, and bacterial exposure), and which contribute to the epigenetic mechanisms underlying the persistent programming of immune functions and allergic diseases. This knowledge will help to improve approaches to nutrition in early life and help prevent allergies in the future. Frontiers Media S.A. 2020-10-21 /pmc/articles/PMC7641638/ /pubmed/33193294 http://dx.doi.org/10.3389/fimmu.2020.02141 Text en Copyright © 2020 Esch, Porbahaie, Abbring, Garssen, Potaczek, Savelkoul and Neerven. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology van Esch, Betty C. A. M. Porbahaie, Mojtaba Abbring, Suzanne Garssen, Johan Potaczek, Daniel P. Savelkoul, Huub F. J. van Neerven, R. J. Joost The Impact of Milk and Its Components on Epigenetic Programming of Immune Function in Early Life and Beyond: Implications for Allergy and Asthma |
title | The Impact of Milk and Its Components on Epigenetic Programming of Immune Function in Early Life and Beyond: Implications for Allergy and Asthma |
title_full | The Impact of Milk and Its Components on Epigenetic Programming of Immune Function in Early Life and Beyond: Implications for Allergy and Asthma |
title_fullStr | The Impact of Milk and Its Components on Epigenetic Programming of Immune Function in Early Life and Beyond: Implications for Allergy and Asthma |
title_full_unstemmed | The Impact of Milk and Its Components on Epigenetic Programming of Immune Function in Early Life and Beyond: Implications for Allergy and Asthma |
title_short | The Impact of Milk and Its Components on Epigenetic Programming of Immune Function in Early Life and Beyond: Implications for Allergy and Asthma |
title_sort | impact of milk and its components on epigenetic programming of immune function in early life and beyond: implications for allergy and asthma |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7641638/ https://www.ncbi.nlm.nih.gov/pubmed/33193294 http://dx.doi.org/10.3389/fimmu.2020.02141 |
work_keys_str_mv | AT vaneschbettycam theimpactofmilkanditscomponentsonepigeneticprogrammingofimmunefunctioninearlylifeandbeyondimplicationsforallergyandasthma AT porbahaiemojtaba theimpactofmilkanditscomponentsonepigeneticprogrammingofimmunefunctioninearlylifeandbeyondimplicationsforallergyandasthma AT abbringsuzanne theimpactofmilkanditscomponentsonepigeneticprogrammingofimmunefunctioninearlylifeandbeyondimplicationsforallergyandasthma AT garssenjohan theimpactofmilkanditscomponentsonepigeneticprogrammingofimmunefunctioninearlylifeandbeyondimplicationsforallergyandasthma AT potaczekdanielp theimpactofmilkanditscomponentsonepigeneticprogrammingofimmunefunctioninearlylifeandbeyondimplicationsforallergyandasthma AT savelkoulhuubfj theimpactofmilkanditscomponentsonepigeneticprogrammingofimmunefunctioninearlylifeandbeyondimplicationsforallergyandasthma AT vanneervenrjjoost theimpactofmilkanditscomponentsonepigeneticprogrammingofimmunefunctioninearlylifeandbeyondimplicationsforallergyandasthma AT vaneschbettycam impactofmilkanditscomponentsonepigeneticprogrammingofimmunefunctioninearlylifeandbeyondimplicationsforallergyandasthma AT porbahaiemojtaba impactofmilkanditscomponentsonepigeneticprogrammingofimmunefunctioninearlylifeandbeyondimplicationsforallergyandasthma AT abbringsuzanne impactofmilkanditscomponentsonepigeneticprogrammingofimmunefunctioninearlylifeandbeyondimplicationsforallergyandasthma AT garssenjohan impactofmilkanditscomponentsonepigeneticprogrammingofimmunefunctioninearlylifeandbeyondimplicationsforallergyandasthma AT potaczekdanielp impactofmilkanditscomponentsonepigeneticprogrammingofimmunefunctioninearlylifeandbeyondimplicationsforallergyandasthma AT savelkoulhuubfj impactofmilkanditscomponentsonepigeneticprogrammingofimmunefunctioninearlylifeandbeyondimplicationsforallergyandasthma AT vanneervenrjjoost impactofmilkanditscomponentsonepigeneticprogrammingofimmunefunctioninearlylifeandbeyondimplicationsforallergyandasthma |