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Association between Bone Mineral Density and Severity of Chronic Kidney Disease

OBJECTIVE: We sought to evaluate the association between femoral neck (FN) and lumbar spine (LS) bone mineral densities (BMDs) with severity of chronic kidney disease (CKD) and prevalence of osteopenia or osteoporosis (OP) among the CKD group. METHODS: Cross-sectional data from 11050 participants ag...

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Autores principales: Huang, Jin-Feng, Zheng, Xuan-Qi, Sun, Xiao-Lei, Zhou, Xiao, Liu, Jian, Li, Yan Michael, Wang, Xiang-Yang, Zhang, Xiao-Lei, Wu, Ai-Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7641666/
https://www.ncbi.nlm.nih.gov/pubmed/33193760
http://dx.doi.org/10.1155/2020/8852690
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author Huang, Jin-Feng
Zheng, Xuan-Qi
Sun, Xiao-Lei
Zhou, Xiao
Liu, Jian
Li, Yan Michael
Wang, Xiang-Yang
Zhang, Xiao-Lei
Wu, Ai-Min
author_facet Huang, Jin-Feng
Zheng, Xuan-Qi
Sun, Xiao-Lei
Zhou, Xiao
Liu, Jian
Li, Yan Michael
Wang, Xiang-Yang
Zhang, Xiao-Lei
Wu, Ai-Min
author_sort Huang, Jin-Feng
collection PubMed
description OBJECTIVE: We sought to evaluate the association between femoral neck (FN) and lumbar spine (LS) bone mineral densities (BMDs) with severity of chronic kidney disease (CKD) and prevalence of osteopenia or osteoporosis (OP) among the CKD group. METHODS: Cross-sectional data from 11050 participants aged ≥20 years from the National Health and Nutrition Examination Survey (NHANES) were analyzed. Specifically, Pearson correlation was applied to analyze the relationship between BMD and estimated glomerular filtration rate (eGFR). General linear models (GLMs) were adjusted for potential confounders and used to analyze mean BMD, based on CKD and CKD stages. RESULTS: FN BMD was positively correlated with the eGFR in the total and male CKD, but not in the female CKD population. LS BMD was not significantly associated with eGFR. After controlling for partial correlations, FN T-score was positively correlated with the eGFR in the total at-risk population. According to FN BMD, OP prevalence was positively associated with CKD stage. However, according to LS BMD, there was no significant association between OP and CKD stage. CONCLUSION: Our results may explain the higher prevalence of hip fracture, relative to that of the spine, among CKD patients and generate meaningful insights to guide care, prevention, and treatment regimens for CKD patients. However, the fact that this was a cross-sectional study may limit the possibility of drawing concrete conclusions. Nevertheless, these findings open up a new frontier for further studies to uncover the higher decrease of FN BMD compared to LS BMD among CKD cases.
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spelling pubmed-76416662020-11-13 Association between Bone Mineral Density and Severity of Chronic Kidney Disease Huang, Jin-Feng Zheng, Xuan-Qi Sun, Xiao-Lei Zhou, Xiao Liu, Jian Li, Yan Michael Wang, Xiang-Yang Zhang, Xiao-Lei Wu, Ai-Min Int J Endocrinol Research Article OBJECTIVE: We sought to evaluate the association between femoral neck (FN) and lumbar spine (LS) bone mineral densities (BMDs) with severity of chronic kidney disease (CKD) and prevalence of osteopenia or osteoporosis (OP) among the CKD group. METHODS: Cross-sectional data from 11050 participants aged ≥20 years from the National Health and Nutrition Examination Survey (NHANES) were analyzed. Specifically, Pearson correlation was applied to analyze the relationship between BMD and estimated glomerular filtration rate (eGFR). General linear models (GLMs) were adjusted for potential confounders and used to analyze mean BMD, based on CKD and CKD stages. RESULTS: FN BMD was positively correlated with the eGFR in the total and male CKD, but not in the female CKD population. LS BMD was not significantly associated with eGFR. After controlling for partial correlations, FN T-score was positively correlated with the eGFR in the total at-risk population. According to FN BMD, OP prevalence was positively associated with CKD stage. However, according to LS BMD, there was no significant association between OP and CKD stage. CONCLUSION: Our results may explain the higher prevalence of hip fracture, relative to that of the spine, among CKD patients and generate meaningful insights to guide care, prevention, and treatment regimens for CKD patients. However, the fact that this was a cross-sectional study may limit the possibility of drawing concrete conclusions. Nevertheless, these findings open up a new frontier for further studies to uncover the higher decrease of FN BMD compared to LS BMD among CKD cases. Hindawi 2020-10-26 /pmc/articles/PMC7641666/ /pubmed/33193760 http://dx.doi.org/10.1155/2020/8852690 Text en Copyright © 2020 Jin-Feng Huang et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Huang, Jin-Feng
Zheng, Xuan-Qi
Sun, Xiao-Lei
Zhou, Xiao
Liu, Jian
Li, Yan Michael
Wang, Xiang-Yang
Zhang, Xiao-Lei
Wu, Ai-Min
Association between Bone Mineral Density and Severity of Chronic Kidney Disease
title Association between Bone Mineral Density and Severity of Chronic Kidney Disease
title_full Association between Bone Mineral Density and Severity of Chronic Kidney Disease
title_fullStr Association between Bone Mineral Density and Severity of Chronic Kidney Disease
title_full_unstemmed Association between Bone Mineral Density and Severity of Chronic Kidney Disease
title_short Association between Bone Mineral Density and Severity of Chronic Kidney Disease
title_sort association between bone mineral density and severity of chronic kidney disease
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7641666/
https://www.ncbi.nlm.nih.gov/pubmed/33193760
http://dx.doi.org/10.1155/2020/8852690
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