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Keratinocyte Function in Normal and Diabetic Wounds and Modulation by FOXO1

Diabetes has a significant and negative impact on wound healing, which involves complex interactions between multiple cell types. Keratinocytes play a crucial role in the healing process by rapidly covering dermal and mucosal wound surfaces to reestablish an epithelial barrier with the outside envir...

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Detalles Bibliográficos
Autores principales: Wang, Yulan, Graves, Dana T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7641706/
https://www.ncbi.nlm.nih.gov/pubmed/33195703
http://dx.doi.org/10.1155/2020/3714704
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author Wang, Yulan
Graves, Dana T.
author_facet Wang, Yulan
Graves, Dana T.
author_sort Wang, Yulan
collection PubMed
description Diabetes has a significant and negative impact on wound healing, which involves complex interactions between multiple cell types. Keratinocytes play a crucial role in the healing process by rapidly covering dermal and mucosal wound surfaces to reestablish an epithelial barrier with the outside environment. Keratinocytes produce multiple factors to promote reepithelialization and produce factors that enhance connective tissue repair through the elaboration of mediators that stimulate angiogenesis and production of connective tissue matrix. Among the factors that keratinocytes produce to aid healing are transforming growth factor-β (TGF-β), vascular endothelial growth factor-A (VEGF-A), connective tissue growth factor (CTGF), and antioxidants. In a diabetic environment, this program is disrupted, and keratinocytes fail to produce growth factors and instead switch to a program that is detrimental to healing. Changes in keratinocyte behavior have been linked to high glucose and advanced glycation end products that alter the activities of the transcription factor, FOXO1. This review examines reepithelialization and factors produced by keratinocytes that upregulate connective tissue healing and angiogenesis and how they are altered by diabetes.
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spelling pubmed-76417062020-11-13 Keratinocyte Function in Normal and Diabetic Wounds and Modulation by FOXO1 Wang, Yulan Graves, Dana T. J Diabetes Res Review Article Diabetes has a significant and negative impact on wound healing, which involves complex interactions between multiple cell types. Keratinocytes play a crucial role in the healing process by rapidly covering dermal and mucosal wound surfaces to reestablish an epithelial barrier with the outside environment. Keratinocytes produce multiple factors to promote reepithelialization and produce factors that enhance connective tissue repair through the elaboration of mediators that stimulate angiogenesis and production of connective tissue matrix. Among the factors that keratinocytes produce to aid healing are transforming growth factor-β (TGF-β), vascular endothelial growth factor-A (VEGF-A), connective tissue growth factor (CTGF), and antioxidants. In a diabetic environment, this program is disrupted, and keratinocytes fail to produce growth factors and instead switch to a program that is detrimental to healing. Changes in keratinocyte behavior have been linked to high glucose and advanced glycation end products that alter the activities of the transcription factor, FOXO1. This review examines reepithelialization and factors produced by keratinocytes that upregulate connective tissue healing and angiogenesis and how they are altered by diabetes. Hindawi 2020-10-28 /pmc/articles/PMC7641706/ /pubmed/33195703 http://dx.doi.org/10.1155/2020/3714704 Text en Copyright © 2020 Yulan Wang and Dana T. Graves. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Wang, Yulan
Graves, Dana T.
Keratinocyte Function in Normal and Diabetic Wounds and Modulation by FOXO1
title Keratinocyte Function in Normal and Diabetic Wounds and Modulation by FOXO1
title_full Keratinocyte Function in Normal and Diabetic Wounds and Modulation by FOXO1
title_fullStr Keratinocyte Function in Normal and Diabetic Wounds and Modulation by FOXO1
title_full_unstemmed Keratinocyte Function in Normal and Diabetic Wounds and Modulation by FOXO1
title_short Keratinocyte Function in Normal and Diabetic Wounds and Modulation by FOXO1
title_sort keratinocyte function in normal and diabetic wounds and modulation by foxo1
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7641706/
https://www.ncbi.nlm.nih.gov/pubmed/33195703
http://dx.doi.org/10.1155/2020/3714704
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