Isoorientin Inhibits Inflammation in Macrophages and Endotoxemia Mice by Regulating Glycogen Synthase Kinase 3β

Isoorientin has anti-inflammatory effects; however, the mechanism remains unclear. We previously found isoorientin is an inhibitor of glycogen synthase kinase 3β (GSK3β) in vitro. Overactivation of GSK3β is associated with inflammatory responses. GSK3β is inactivated by phosphorylation at Ser9 (i.e....

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Detalles Bibliográficos
Autores principales: Li, Yingui, Zhao, Yijing, Tan, Xiaoqin, Liu, Jiayan, Zhi, Yingkun, Yi, Lang, Bai, Shasha, Du, Qun, Li, Qing X., Dong, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7641714/
https://www.ncbi.nlm.nih.gov/pubmed/33192176
http://dx.doi.org/10.1155/2020/8704146

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7641714/
https://www.ncbi.nlm.nih.gov/pubmed/33192176
http://dx.doi.org/10.1155/2020/8704146

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