Cargando…

Structural basis of prostate-specific membrane antigen recognition by the A9g RNA aptamer

Prostate-specific membrane antigen (PSMA) is a well-characterized tumor marker associated with prostate cancer and neovasculature of most solid tumors. PSMA-specific ligands are thus being developed to deliver imaging or therapeutic agents to cancer cells. Here, we report on a crystal structure of h...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ptacek, Jakub, Zhang, Dong, Qiu, Liming, Kruspe, Sven, Motlova, Lucia, Kolenko, Petr, Novakova, Zora, Shubham, Shambhavi, Havlinova, Barbora, Baranova, Petra, Chen, Shi-Jie, Zou, Xiaoqin, Giangrande, Paloma, Barinka, Cyril
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7641732/ https://www.ncbi.nlm.nih.gov/pubmed/32525981 http://dx.doi.org/10.1093/nar/gkaa494

Ejemplares similares

Aptamer-siRNA Chimeras: Discovery, Progress, and Future Prospects
por: Kruspe, Sven, et al.
Publicado: (2017)

Comprehensive Mechanistic View of the Hydrolysis of Oxadiazole-Based Inhibitors by Histone Deacetylase 6 (HDAC6)
por: Motlová, Lucia, et al.
Publicado: (2023)

Human histone deacetylase 6 shows strong preference for tubulin dimers over assembled microtubules
por: Skultetyova, Lubica, et al.
Publicado: (2017)

Generation and characterization of human U-2 OS cell lines with the CRISPR/Cas9-edited protoporphyrinogen oxidase IX gene
por: Novakova, Zora, et al.
Publicado: (2022)

Selectivity of Hydroxamate- and Difluoromethyloxadiazole-Based Inhibitors of Histone Deacetylase 6 In Vitro and in Cells
por: Ptacek, Jakub, et al.
Publicado: (2023)

Heterologous expression and purification of recombinant human protoporphyrinogen oxidase IX: A comparative study
por: Novakova, Zora, et al.
Publicado: (2021)

Engineered Fragments of the PSMA-Specific 5D3 Antibody and Their Functional Characterization
por: Novakova, Zora, et al.
Publicado: (2020)

Anti-prion activity of an RNA aptamer and its structural basis
por: Mashima, Tsukasa, et al.
Publicado: (2013)

Structural basis for high-affinity recognition of aflatoxin B1 by a DNA aptamer
por: Xu, Guohua, et al.
Publicado: (2023)

Conformation-based refinement of 18-mer DNA structures
por: Svoboda, Jakub, et al.
Publicado: (2023)

Chlorin e6 Conjugated Interleukin-6 Receptor Aptamers Selectively Kill Target Cells Upon Irradiation
por: Kruspe, Sven, et al.
Publicado: (2014)

Arrangements of human telomere DNA quadruplex in physiologically relevant K(+) solutions
por: Renčiuk, D., et al.
Publicado: (2009)

Thrombin–aptamer recognition: a revealed ambiguity
por: Russo Krauss, Irene, et al.
Publicado: (2011)

Structure of an RNA aptamer in complex with the fluorophore tetramethylrhodamine
por: Duchardt-Ferner, Elke, et al.
Publicado: (2020)

High-resolution structures of two complexes between thrombin and thrombin-binding aptamer shed light on the role of cations in the aptamer inhibitory activity
por: Russo Krauss, Irene, et al.
Publicado: (2012)

Structure-guided post-SELEX optimization of an ochratoxin A aptamer
por: Xu, Guohua, et al.
Publicado: (2019)

Aptamers as Diagnostic Tools in Cancer
por: Ruiz Ciancio, Dario, et al.
Publicado: (2018)

Structural basis for DNA strand separation by a hexameric replicative helicase
por: Chaban, Yuriy, et al.
Publicado: (2015)

Thrombin binding aptamer G-quadruplex stabilized by pyrene-modified nucleotides
por: Kovačič, Matic, et al.
Publicado: (2020)

Crystal structures and identification of novel Cd(2+)-specific DNA aptamer
por: Liu, Hehua, et al.
Publicado: (2023)

Thermal stabilisation of the short DNA duplexes by acridine-4-carboxamide derivatives
por: Kostelansky, Filip, et al.
Publicado: (2022)

Unique quadruplex structure and interaction of an RNA aptamer against bovine prion protein
por: Mashima, Tsukasa, et al.
Publicado: (2009)

Through-bond effects in the ternary complexes of thrombin sandwiched by two DNA aptamers
por: Pica, Andrea, et al.
Publicado: (2017)

Broad-spectrum aptamer inhibitors of HIV reverse transcriptase closely mimic natural substrates
por: Ditzler, Mark A., et al.
Publicado: (2011)

Single-molecule detection of folding and unfolding of the G-quadruplex aptamer in a nanopore nanocavity
por: Shim, Ji Wook, et al.
Publicado: (2009)

Different duplex/quadruplex junctions determine the properties of anti-thrombin aptamers with mixed folding
por: Russo Krauss, Irene, et al.
Publicado: (2016)

Folding of the cocaine aptamer studied by EPR and fluorescence spectroscopies using the bifunctional spectroscopic probe Ç
por: Cekan, Pavol, et al.
Publicado: (2009)

Structural basis of σ appropriation
por: Shi, Jing, et al.
Publicado: (2019)

A new modified thrombin binding aptamer containing a 5′–5′ inversion of polarity site
por: Martino, Luigi, et al.
Publicado: (2006)

Crystal structures of thrombin in complex with chemically modified thrombin DNA aptamers reveal the origins of enhanced affinity
por: Dolot, Rafal, et al.
Publicado: (2018)

Several structural motifs cooperate in determining the highly effective anti-thrombin activity of NU172 aptamer
por: Troisi, Romualdo, et al.
Publicado: (2018)

RNA origami scaffolds facilitate cryo-EM characterization of a Broccoli–Pepper aptamer FRET pair
por: Sampedro Vallina, Néstor, et al.
Publicado: (2023)

Rapid Identification of Cell-Specific, Internalizing RNA Aptamers with Bioinformatics Analyses of a Cell-Based Aptamer Selection
por: Thiel, William H., et al.
Publicado: (2012)

Aptamers in Bordeaux, 24–25 June 2016
por: Toulmé, Jean-Jacques, et al.
Publicado: (2017)

Continuous Activity Assay for HDAC11 Enabling Reevaluation of HDAC Inhibitors
por: Kutil, Zsófia, et al.
Publicado: (2019)

Dissecting the influence of Mg(2+) on 3D architecture and ligand-binding of the guanine-sensing riboswitch aptamer domain
por: Buck, Janina, et al.
Publicado: (2010)

Influence of ground-state structure and Mg(2+) binding on folding kinetics of the guanine-sensing riboswitch aptamer domain
por: Buck, Janina, et al.
Publicado: (2011)

Ion-dependent conformational switching by a DNA aptamer that induces remyelination in a mouse model of multiple sclerosis
por: Smestad, John, et al.
Publicado: (2013)

Structure analysis of free and bound states of an RNA aptamer against ribosomal protein S8 from Bacillus anthracis
por: Davlieva, Milya, et al.
Publicado: (2014)

Aptamer-enabled uptake of small molecule ligands
por: Auwardt, Supipi Liyamali, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_mg3jiig0ltmjplihtu9hu7pr8e