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Molecular determinants of MED1 interaction with the DNA bound VDR–RXR heterodimer

The MED1 subunit of the Mediator complex is an essential coactivator of nuclear receptor-mediated transcriptional activation. While structural requirements for ligand-dependent binding of classical coactivator motifs of MED1 to numerous nuclear receptor ligand-binding domains have been fully elucida...

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Detalles Bibliográficos
Autores principales:	Belorusova, Anna Y, Bourguet, Maxime, Hessmann, Steve, Chalhoub, Sandra, Kieffer, Bruno, Cianférani, Sarah, Rochel, Natacha
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7641746/ https://www.ncbi.nlm.nih.gov/pubmed/32990725 http://dx.doi.org/10.1093/nar/gkaa775

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