Asymmetrical effects of deafness-associated mitochondrial DNA 7516delA mutation on the processing of RNAs in the H-strand and L-strand polycistronic transcripts

In this report, we investigated the molecular mechanism underlying a deafness-associated m.7516delA mutation affecting the 5′ end processing sites of mitochondrial tRNA(Asp) and tRNA(Ser(UCN)). An in vitro processing experiment demonstrated that m.7516delA mutation caused the aberrant 5′ end process...

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Detalles Bibliográficos
Autores principales: Xiao, Yun, Wang, Meng, He, Qiufen, Xu, Lei, Zhang, Qinghai, Meng, Feilong, Jia, Zidong, Zhang, Fengguo, Wang, Haibo, Guan, Min-Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7641755/
https://www.ncbi.nlm.nih.gov/pubmed/33045734
http://dx.doi.org/10.1093/nar/gkaa860

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