Cargando…

A genetic screen for suppressors of hyper-repression of the fission yeast PHO regulon by Pol2 CTD mutation T4A implicates inositol 1-pyrophosphates as agonists of precocious lncRNA transcription termination

Fission yeast phosphate homeostasis genes are repressed in phosphate-rich medium by transcription of upstream lncRNAs that interferes with activation of the flanking mRNA promoters. lncRNA control of PHO gene expression is influenced by the Thr4 phospho-site in the RNA polymerase II CTD and the 3′ p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Garg, Angad, Shuman, Stewart, Schwer, Beate
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Gene regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7641756/ https://www.ncbi.nlm.nih.gov/pubmed/33010152 http://dx.doi.org/10.1093/nar/gkaa776

Ejemplares similares

Genetic screen for suppression of transcriptional interference reveals fission yeast 14–3–3 protein Rad24 as an antagonist of precocious Pol2 transcription termination
por: Garg, Angad, et al.
Publicado: (2021)

Inositol pyrophosphates impact phosphate homeostasis via modulation of RNA 3′ processing and transcription termination
por: Sanchez, Ana M, et al.
Publicado: (2019)

Genetic interactions and transcriptomics implicate fission yeast CTD prolyl isomerase Pin1 as an agent of RNA 3′ processing and transcription termination that functions via its effects on CTD phosphatase Ssu72
por: Sanchez, Ana M, et al.
Publicado: (2020)

Distinctive structural basis for DNA recognition by the fission yeast Zn(2)Cys(6) transcription factor Pho7 and its role in phosphate homeostasis
por: Garg, Angad, et al.
Publicado: (2018)

Cellular responses to long-term phosphate starvation of fission yeast: Maf1 determines fate choice between quiescence and death associated with aberrant tRNA biogenesis
por: Garg, Angad, et al.
Publicado: (2023)

Splicing inhibition decreases phosphorylation level of Ser2 in Pol II CTD
por: Koga, Mitsunori, et al.
Publicado: (2015)

The Pol IV largest subunit CTD quantitatively affects siRNA levels guiding RNA-directed DNA methylation
por: Wendte, Jered M, et al.
Publicado: (2019)

A feed forward circuit comprising Spt6, Ctk1 and PAF regulates Pol II CTD phosphorylation and transcription elongation
por: Dronamraju, Raghuvar, et al.
Publicado: (2014)

Chromatin structure-dependent conformations of the H1 CTD
por: Fang, He, et al.
Publicado: (2016)

Phospho-site mutants of the RNA Polymerase II C-terminal domain alter subtelomeric gene expression and chromatin modification state in fission yeast
por: Inada, Maki, et al.
Publicado: (2016)

Activities and Structure-Function Analysis of Fission Yeast Inositol Pyrophosphate (IPP) Kinase-Pyrophosphatase Asp1 and Its Impact on Regulation of pho1 Gene Expression
por: Benjamin, Bradley, et al.
Publicado: (2022)

Rpb4/7 facilitates RNA polymerase II CTD dephosphorylation
por: Allepuz-Fuster, Paula, et al.
Publicado: (2014)

Brd4 activates P-TEFb for RNA polymerase II CTD phosphorylation
por: Itzen, Friederike, et al.
Publicado: (2014)

Toward the identification and regulation of the Arabidopsis thaliana ABI3 regulon
por: Mönke, Gudrun, et al.
Publicado: (2012)

The PurR regulon in Escherichia coli K-12 MG1655
por: Cho, Byung-Kwan, et al.
Publicado: (2011)

DNA mapping and kinetic modeling of the HrdB regulon in Streptomyces coelicolor
por: Šmídová, Klára, et al.
Publicado: (2019)

CTD serine-2 plays a critical role in splicing and termination factor recruitment to RNA polymerase II in vivo
por: Gu, Bo, et al.
Publicado: (2013)

Comprehensive insights into Mycobacterium tuberculosis DevR (DosR) regulon activation switch
por: Chauhan, Santosh, et al.
Publicado: (2011)

The MazF-regulon: a toolbox for the post-transcriptional stress response in Escherichia coli
por: Sauert, Martina, et al.
Publicado: (2016)

SAYP and Brahma are important for ‘repressive’ and ‘transient’ Pol II pausing
por: Vorobyeva, Nadezhda E., et al.
Publicado: (2012)

Transfer activation of SXT/R391 integrative and conjugative elements: unraveling the SetCD regulon
por: Poulin-Laprade, Dominic, et al.
Publicado: (2015)

Functional interaction of Rpb1 and Spt5 C-terminal domains in co-transcriptional histone modification
por: Mbogning, Jean, et al.
Publicado: (2015)

The RSC chromatin remodeling complex has a crucial role in the complete remodeler set for yeast PHO5 promoter opening
por: Musladin, Sanja, et al.
Publicado: (2014)

The genomic region of the 3′ untranslated region (3′UTR) of PHO84, rather than the antisense RNA, promotes gene repression
por: Hegazy, Youssef A, et al.
Publicado: (2023)

Wide-ranging and unexpected consequences of altered Pol II catalytic activity in vivo
por: Malik, Indranil, et al.
Publicado: (2017)

Release of promoter–proximal paused Pol II in response to histone deacetylase inhibition
por: Vaid, Roshan, et al.
Publicado: (2020)

The FurA regulon in Anabaena sp. PCC 7120: in silico prediction and experimental validation of novel target genes
por: González, Andrés, et al.
Publicado: (2014)

A novel sigma factor reveals a unique regulon controlling cell-specific recombination in Mycoplasma genitalium
por: Torres-Puig, Sergi, et al.
Publicado: (2015)

Differential binding of the related transcription factors Pho4 and Cbf1 can tune the sensitivity of promoters to different levels of an induction signal
por: Aow, Jonathan S. Z., et al.
Publicado: (2013)

Diverse control of metabolism and other cellular processes in Streptomyces coelicolor by the PhoP transcription factor: genome-wide identification of in vivo targets
por: Allenby, Nicholas E. E., et al.
Publicado: (2012)

Transcriptional profiling of fission yeast RNA polymerase II CTD mutants
por: Garg, Angad, et al.
Publicado: (2021)

Cleavage-Polyadenylation Factor Cft1 and SPX Domain Proteins Are Agents of Inositol Pyrophosphate Toxicosis in Fission Yeast
por: Schwer, Beate, et al.
Publicado: (2022)

Oxidative stress rapidly stabilizes promoter-proximal paused Pol II across the human genome
por: Nilson, Kyle A., et al.
Publicado: (2017)

The cellular growth rate controls overall mRNA turnover, and modulates either transcription or degradation rates of particular gene regulons
por: García-Martínez, José, et al.
Publicado: (2016)

Loss of EZH2 results in precocious mammary gland development and activation of STAT5-dependent genes
por: Yoo, Kyung Hyun, et al.
Publicado: (2015)

The NRPD1 N-terminus contains a Pol IV-specific motif that is critical for genome surveillance in Arabidopsis
por: Ferrafiat, Laura, et al.
Publicado: (2019)

In vitro transcription profiling of the σ(S) subunit of bacterial RNA polymerase: re-definition of the σ(S) regulon and identification of σ(S)-specific promoter sequence elements
por: Maciąg, Anna, et al.
Publicado: (2011)

Characterization of the RpoN regulon reveals differential regulation of T6SS and new flagellar operons in Vibrio cholerae O37 strain V52
por: Dong, Tao G., et al.
Publicado: (2012)

Chromatin architectures at fission yeast transcriptional promoters and replication origins
por: Givens, Robert M., et al.
Publicado: (2012)

Gcn5 facilitates Pol II progression, rather than recruitment to nucleosome-depleted stress promoters, in Schizosaccharomyces pombe
por: Sansó, Miriam, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_lo8nlgltqr3n3a32rgn15qhvbi