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Stabilization of G-quadruplex DNA structures in Schizosaccharomyces pombe causes single-strand DNA lesions and impedes DNA replication

G-quadruplex (G4) structures are stable non-canonical DNA structures that are implicated in the regulation of many cellular pathways. We show here that the G4-stabilizing compound PhenDC3 causes growth defects in Schizosaccharomyces pombe cells, especially during S-phase in synchronized cultures. By...

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Detalles Bibliográficos
Autores principales:	Obi, Ikenna, Rentoft, Matilda, Singh, Vandana, Jamroskovic, Jan, Chand, Karam, Chorell, Erik, Westerlund, Fredrik, Sabouri, Nasim
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7641769/ https://www.ncbi.nlm.nih.gov/pubmed/33045725 http://dx.doi.org/10.1093/nar/gkaa820

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