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Combined treatment of mitoxantrone sensitizes breast cancer cells to rapalogs through blocking eEF-2K-mediated activation of Akt and autophagy

Oncogenic activation of the mTOR signaling pathway occurs frequently in tumor cells and contributes to the devastating features of cancer, including breast cancer. mTOR inhibitors rapalogs are promising anticancer agents in clinical trials; however, rapalogs resistance remains an unresolved clinical...

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Detalles Bibliográficos
Autores principales:	Guan, Yidi, Jiang, Shilong, Ye, Wenling, Ren, Xingcong, Wang, Xinluan, Zhang, Yi, Yin, Mingzhu, Wang, Kuansong, Tao, Yongguang, Yang, JinMing, Cao, Dongsheng, Cheng, Yan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7642277/ https://www.ncbi.nlm.nih.gov/pubmed/33144562 http://dx.doi.org/10.1038/s41419-020-03153-x

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