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Evolution from adherent to suspension: systems biology of HEK293 cell line development
The need for new safe and efficacious therapies has led to an increased focus on biologics produced in mammalian cells. The human cell line HEK293 has bio-synthetic potential for human-like production attributes and is currently used for manufacturing of several therapeutic proteins and viral vector...
Autores principales: | Malm, Magdalena, Saghaleyni, Rasool, Lundqvist, Magnus, Giudici, Marco, Chotteau, Veronique, Field, Ray, Varley, Paul G., Hatton, Diane, Grassi, Luigi, Svensson, Thomas, Nielsen, Jens, Rockberg, Johan |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7642379/ https://www.ncbi.nlm.nih.gov/pubmed/33149219 http://dx.doi.org/10.1038/s41598-020-76137-8 |
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