Preconditioning the immature lung with enhanced Nrf2 activity protects against oxidant-induced hypoalveolarization in mice

Bronchopulmonary dysplasia (BPD) is a chronic disease of preterm babies with poor clinical outcomes. Nrf2 transcription factor is crucial for cytoprotective response, whereas Keap1—an endogenous inhibitor of Nrf2 signaling—dampens these protective responses. Nrf2-sufficient (wild type) newborn mice...

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Detalles Bibliográficos
Autores principales: Tamatam, Chandra M., Reddy, Narsa M., Potteti, Haranatha R., Ankireddy, Aparna, Noone, Patrick M., Yamamoto, Masayuki, Kensler, Thomas W., Reddy, Sekhar P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7642393/
https://www.ncbi.nlm.nih.gov/pubmed/33149211
http://dx.doi.org/10.1038/s41598-020-75834-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7642393/
https://www.ncbi.nlm.nih.gov/pubmed/33149211
http://dx.doi.org/10.1038/s41598-020-75834-8

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