Perturbed structural dynamics underlie inhibition and altered efflux of the multidrug resistance pump AcrB

Resistance–nodulation–division efflux pumps play a key role in inherent and evolved multidrug resistance in bacteria. AcrB, a prototypical member of this protein family, extrudes a wide range of antimicrobial agents out of bacteria. Although high-resolution structures exist for AcrB, its conformatio...

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Detalles Bibliográficos
Autores principales: Reading, Eamonn, Ahdash, Zainab, Fais, Chiara, Ricci, Vito, Wang-Kan, Xuan, Grimsey, Elizabeth, Stone, Jack, Malloci, Giuliano, Lau, Andy M., Findlay, Heather, Konijnenberg, Albert, Booth, Paula J., Ruggerone, Paolo, Vargiu, Attilio V., Piddock, Laura J. V., Politis, Argyris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7642415/
https://www.ncbi.nlm.nih.gov/pubmed/33149158
http://dx.doi.org/10.1038/s41467-020-19397-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7642415/
https://www.ncbi.nlm.nih.gov/pubmed/33149158
http://dx.doi.org/10.1038/s41467-020-19397-2

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