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Association Between Occlusion Type and Etiology of Acute Intracranial Large Artery Occlusion

Objective: To investigate the diagnostic efficiency of truncal-type occlusion and branching-site occlusion in determining the etiology of intracranial large artery occlusion related acute ischemic stroke (AIS). Methods: Patients with intracranial large artery occlusion related AIS who received stent...

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Autores principales: Chuming, Huang, Yifan, Hong, Ke, Xu, Chukai, Xu, Weijie, Zhang, Hui, Li, Guoyi, Peng, Xiaoyong, Zhang, Peifeng, Zhang, Chuwei, Cai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7642447/
https://www.ncbi.nlm.nih.gov/pubmed/33193040
http://dx.doi.org/10.3389/fneur.2020.582388
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author Chuming, Huang
Yifan, Hong
Ke, Xu
Chukai, Xu
Weijie, Zhang
Hui, Li
Guoyi, Peng
Xiaoyong, Zhang
Peifeng, Zhang
Chuwei, Cai
author_facet Chuming, Huang
Yifan, Hong
Ke, Xu
Chukai, Xu
Weijie, Zhang
Hui, Li
Guoyi, Peng
Xiaoyong, Zhang
Peifeng, Zhang
Chuwei, Cai
author_sort Chuming, Huang
collection PubMed
description Objective: To investigate the diagnostic efficiency of truncal-type occlusion and branching-site occlusion in determining the etiology of intracranial large artery occlusion related acute ischemic stroke (AIS). Methods: Patients with intracranial large artery occlusion related AIS who received stent retriever (SR) thrombectomy from November 2014 to June 2019 were included in the study. All patients underwent angiography before SR thrombectomy, which was used to evaluate the occlusion type. Differences in the distribution of occlusion types in intracranial atherosclerosis (ICAS) and embolism were assessed, and the diagnostic indicators, including the area under the ROC curve (AUC), sensitivity, and specificity were calculated. Results: Of the 115 AIS patients with intracranial large artery occlusion, 42 were classified as having ICAS, and 73 having an embolism. In the ICAS group, branching-site occlusion was responsible for 3 (7%) cases and truncal-type occlusion for 39 (93%) cases, while in the embolism group, branching-site occlusion was responsible for 66 (90%) cases and truncal-type occlusion for 7 (10%) cases; the difference was statistically significant (all P < 0.01). The AUC for ICAS predicted by truncal-type occlusion was 0.916, with a sensitivity of 92.86%, and specificity of 90.41%. Conclusion: Truncal-type occlusion showed a high predictability of ICAS. Determine the etiology of intracranial large artery occlusion related AIS before SR thrombectomy may be most helpful in setting up optimal endovascular treatment strategies.
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spelling pubmed-76424472020-11-13 Association Between Occlusion Type and Etiology of Acute Intracranial Large Artery Occlusion Chuming, Huang Yifan, Hong Ke, Xu Chukai, Xu Weijie, Zhang Hui, Li Guoyi, Peng Xiaoyong, Zhang Peifeng, Zhang Chuwei, Cai Front Neurol Neurology Objective: To investigate the diagnostic efficiency of truncal-type occlusion and branching-site occlusion in determining the etiology of intracranial large artery occlusion related acute ischemic stroke (AIS). Methods: Patients with intracranial large artery occlusion related AIS who received stent retriever (SR) thrombectomy from November 2014 to June 2019 were included in the study. All patients underwent angiography before SR thrombectomy, which was used to evaluate the occlusion type. Differences in the distribution of occlusion types in intracranial atherosclerosis (ICAS) and embolism were assessed, and the diagnostic indicators, including the area under the ROC curve (AUC), sensitivity, and specificity were calculated. Results: Of the 115 AIS patients with intracranial large artery occlusion, 42 were classified as having ICAS, and 73 having an embolism. In the ICAS group, branching-site occlusion was responsible for 3 (7%) cases and truncal-type occlusion for 39 (93%) cases, while in the embolism group, branching-site occlusion was responsible for 66 (90%) cases and truncal-type occlusion for 7 (10%) cases; the difference was statistically significant (all P < 0.01). The AUC for ICAS predicted by truncal-type occlusion was 0.916, with a sensitivity of 92.86%, and specificity of 90.41%. Conclusion: Truncal-type occlusion showed a high predictability of ICAS. Determine the etiology of intracranial large artery occlusion related AIS before SR thrombectomy may be most helpful in setting up optimal endovascular treatment strategies. Frontiers Media S.A. 2020-10-22 /pmc/articles/PMC7642447/ /pubmed/33193040 http://dx.doi.org/10.3389/fneur.2020.582388 Text en Copyright © 2020 Chuming, Yifan, Ke, Chukai, Weijie, Hui, Guoyi, Xiaoyong, Peifeng and Chuwei. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Chuming, Huang
Yifan, Hong
Ke, Xu
Chukai, Xu
Weijie, Zhang
Hui, Li
Guoyi, Peng
Xiaoyong, Zhang
Peifeng, Zhang
Chuwei, Cai
Association Between Occlusion Type and Etiology of Acute Intracranial Large Artery Occlusion
title Association Between Occlusion Type and Etiology of Acute Intracranial Large Artery Occlusion
title_full Association Between Occlusion Type and Etiology of Acute Intracranial Large Artery Occlusion
title_fullStr Association Between Occlusion Type and Etiology of Acute Intracranial Large Artery Occlusion
title_full_unstemmed Association Between Occlusion Type and Etiology of Acute Intracranial Large Artery Occlusion
title_short Association Between Occlusion Type and Etiology of Acute Intracranial Large Artery Occlusion
title_sort association between occlusion type and etiology of acute intracranial large artery occlusion
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7642447/
https://www.ncbi.nlm.nih.gov/pubmed/33193040
http://dx.doi.org/10.3389/fneur.2020.582388
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