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Correlation Between Internal Carotid Artery Tortuosity and Imaging of Cerebral Small Vessel Disease

Background and Purpose: An association between artery tortuosity and neuroimaging of cerebral small vessel disease (SVD) has been reported, especially in the posterior circulation. However, few studies involved the whole magnetic resonance imaging (MRI) spectrum of SVD in association with anterior c...

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Autores principales: Chen, Yuan-Chang, Wei, Xiao-Er, Lu, Jing, Qiao, Rui-Hua, Shen, Xue-Feng, Li, Yue-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7642469/
https://www.ncbi.nlm.nih.gov/pubmed/33193005
http://dx.doi.org/10.3389/fneur.2020.567232
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author Chen, Yuan-Chang
Wei, Xiao-Er
Lu, Jing
Qiao, Rui-Hua
Shen, Xue-Feng
Li, Yue-Hua
author_facet Chen, Yuan-Chang
Wei, Xiao-Er
Lu, Jing
Qiao, Rui-Hua
Shen, Xue-Feng
Li, Yue-Hua
author_sort Chen, Yuan-Chang
collection PubMed
description Background and Purpose: An association between artery tortuosity and neuroimaging of cerebral small vessel disease (SVD) has been reported, especially in the posterior circulation. However, few studies involved the whole magnetic resonance imaging (MRI) spectrum of SVD in association with anterior circulation arterial tortuosity. This study aimed to investigate the relationship between internal carotid artery (ICA) tortuosity and the neuroimaging of SVD. Methods: Data of 1,264 consecutive patients in whom cerebral vessel diseases were suspected and who underwent both MRI and computed tomography angiography were reviewed from a prospective registry. Internal carotid artery tortuosity was evaluated using the tortuosity index (TI), which was defined as the ratio of the vessel centerline length divided by the straight length. Magnetic resonance imaging was used to assess cerebral microbleeds (CMBs), white matter hyperintensities (WMHs), enlarged perivascular spaces (EPVSs), and lacunes. Results: The TIs of the ICA for patients with and without SVD MRI markers were 1.81 ± 0.42 and 1.72 ± 0.33, respectively (P < 0.001). Univariate analysis showed that the ICA TI were positively correlated with each SVD MRI marker (P < 0.001), and the correlation coefficients (r(s)) were 0.57, 0.42, 0.30, and 0.26 for EPVSs, WMHs, CMBs, and lacunes, respectively. The adjusted ORs of the ICA TI were 1.52 (95% CI 1.44–1.60, P < 0.001) for EPVS grade 1, 2.05 (95% CI 1.93–2.18, P < 0.001) for EPVS grades 2–4, and 1.09 (95% CI 1.03–1.15, P = 0.004) for WMH grade 3. Conclusions: The TI of ICA was higher in patients with neuroimaging of SVD. Internal carotid arteries tortuosity was associated with MRI-defined markers of SVD, including EPVS and high-grade WMH, and positively correlated with EPVS severity. Arterial tortuosity might be a risk factor for SVD. This finding may have potential clinical significance for identifying patients with suspected SVD.
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spelling pubmed-76424692020-11-13 Correlation Between Internal Carotid Artery Tortuosity and Imaging of Cerebral Small Vessel Disease Chen, Yuan-Chang Wei, Xiao-Er Lu, Jing Qiao, Rui-Hua Shen, Xue-Feng Li, Yue-Hua Front Neurol Neurology Background and Purpose: An association between artery tortuosity and neuroimaging of cerebral small vessel disease (SVD) has been reported, especially in the posterior circulation. However, few studies involved the whole magnetic resonance imaging (MRI) spectrum of SVD in association with anterior circulation arterial tortuosity. This study aimed to investigate the relationship between internal carotid artery (ICA) tortuosity and the neuroimaging of SVD. Methods: Data of 1,264 consecutive patients in whom cerebral vessel diseases were suspected and who underwent both MRI and computed tomography angiography were reviewed from a prospective registry. Internal carotid artery tortuosity was evaluated using the tortuosity index (TI), which was defined as the ratio of the vessel centerline length divided by the straight length. Magnetic resonance imaging was used to assess cerebral microbleeds (CMBs), white matter hyperintensities (WMHs), enlarged perivascular spaces (EPVSs), and lacunes. Results: The TIs of the ICA for patients with and without SVD MRI markers were 1.81 ± 0.42 and 1.72 ± 0.33, respectively (P < 0.001). Univariate analysis showed that the ICA TI were positively correlated with each SVD MRI marker (P < 0.001), and the correlation coefficients (r(s)) were 0.57, 0.42, 0.30, and 0.26 for EPVSs, WMHs, CMBs, and lacunes, respectively. The adjusted ORs of the ICA TI were 1.52 (95% CI 1.44–1.60, P < 0.001) for EPVS grade 1, 2.05 (95% CI 1.93–2.18, P < 0.001) for EPVS grades 2–4, and 1.09 (95% CI 1.03–1.15, P = 0.004) for WMH grade 3. Conclusions: The TI of ICA was higher in patients with neuroimaging of SVD. Internal carotid arteries tortuosity was associated with MRI-defined markers of SVD, including EPVS and high-grade WMH, and positively correlated with EPVS severity. Arterial tortuosity might be a risk factor for SVD. This finding may have potential clinical significance for identifying patients with suspected SVD. Frontiers Media S.A. 2020-10-22 /pmc/articles/PMC7642469/ /pubmed/33193005 http://dx.doi.org/10.3389/fneur.2020.567232 Text en Copyright © 2020 Chen, Wei, Lu, Qiao, Shen and Li. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Chen, Yuan-Chang
Wei, Xiao-Er
Lu, Jing
Qiao, Rui-Hua
Shen, Xue-Feng
Li, Yue-Hua
Correlation Between Internal Carotid Artery Tortuosity and Imaging of Cerebral Small Vessel Disease
title Correlation Between Internal Carotid Artery Tortuosity and Imaging of Cerebral Small Vessel Disease
title_full Correlation Between Internal Carotid Artery Tortuosity and Imaging of Cerebral Small Vessel Disease
title_fullStr Correlation Between Internal Carotid Artery Tortuosity and Imaging of Cerebral Small Vessel Disease
title_full_unstemmed Correlation Between Internal Carotid Artery Tortuosity and Imaging of Cerebral Small Vessel Disease
title_short Correlation Between Internal Carotid Artery Tortuosity and Imaging of Cerebral Small Vessel Disease
title_sort correlation between internal carotid artery tortuosity and imaging of cerebral small vessel disease
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7642469/
https://www.ncbi.nlm.nih.gov/pubmed/33193005
http://dx.doi.org/10.3389/fneur.2020.567232
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