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Tectorigenin Alleviates Inflammation, Apoptosis, and Ossification in Rat Tendon-Derived Stem Cells via Modulating NF-Kappa B and MAPK Pathways
Tendinopathy is a common musculoskeletal disorder that mainly affects athletes and people of older age. Tumor necrosis factor-α (TNF-α) plays an important role in initiating tendinopathy. Tectorigenin, an extract component of Belam-canda Chinesis, possesses anti-inflammatory and anti-apoptosis activ...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7642480/ https://www.ncbi.nlm.nih.gov/pubmed/33195199 http://dx.doi.org/10.3389/fcell.2020.568894 |
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author | Moqbel, Safwat Adel Abdo Xu, Kai Chen, Zhonggai Xu, Langhai He, Yuezhe Wu, Zhipeng Ma, Chiyuan Ran, Jisheng Wu, Lidong Xiong, Yan |
author_facet | Moqbel, Safwat Adel Abdo Xu, Kai Chen, Zhonggai Xu, Langhai He, Yuezhe Wu, Zhipeng Ma, Chiyuan Ran, Jisheng Wu, Lidong Xiong, Yan |
author_sort | Moqbel, Safwat Adel Abdo |
collection | PubMed |
description | Tendinopathy is a common musculoskeletal disorder that mainly affects athletes and people of older age. Tumor necrosis factor-α (TNF-α) plays an important role in initiating tendinopathy. Tectorigenin, an extract component of Belam-canda Chinesis, possesses anti-inflammatory and anti-apoptosis activity. The present study was established to investigate the role of tectorigenin against the pathogenetic effects of TNF-α on tendon-derived stem cells (TDSCs) in vivo and in vitro. The findings indicated that TNF-α is able to induce TDSC inflammation, apoptosis, and ossification, as well as activate nuclear factor-kappa B and mitogen-activated protein kinase (MAPK). Furthermore, the results confirmed that tectorigenin is able to inhibit the TNF-α-induced inflammation, apoptosis, and ossification. Tectorigenin treatment decreases activation of NF-kappa B and MAPK signaling in TDSCs. Tectorigenin ameliorates tendinopathy in the in vivo rat model. Thus, these data reveal that tectorigenin can serve as a potential treatment for tendinopathy. |
format | Online Article Text |
id | pubmed-7642480 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-76424802020-11-13 Tectorigenin Alleviates Inflammation, Apoptosis, and Ossification in Rat Tendon-Derived Stem Cells via Modulating NF-Kappa B and MAPK Pathways Moqbel, Safwat Adel Abdo Xu, Kai Chen, Zhonggai Xu, Langhai He, Yuezhe Wu, Zhipeng Ma, Chiyuan Ran, Jisheng Wu, Lidong Xiong, Yan Front Cell Dev Biol Cell and Developmental Biology Tendinopathy is a common musculoskeletal disorder that mainly affects athletes and people of older age. Tumor necrosis factor-α (TNF-α) plays an important role in initiating tendinopathy. Tectorigenin, an extract component of Belam-canda Chinesis, possesses anti-inflammatory and anti-apoptosis activity. The present study was established to investigate the role of tectorigenin against the pathogenetic effects of TNF-α on tendon-derived stem cells (TDSCs) in vivo and in vitro. The findings indicated that TNF-α is able to induce TDSC inflammation, apoptosis, and ossification, as well as activate nuclear factor-kappa B and mitogen-activated protein kinase (MAPK). Furthermore, the results confirmed that tectorigenin is able to inhibit the TNF-α-induced inflammation, apoptosis, and ossification. Tectorigenin treatment decreases activation of NF-kappa B and MAPK signaling in TDSCs. Tectorigenin ameliorates tendinopathy in the in vivo rat model. Thus, these data reveal that tectorigenin can serve as a potential treatment for tendinopathy. Frontiers Media S.A. 2020-10-22 /pmc/articles/PMC7642480/ /pubmed/33195199 http://dx.doi.org/10.3389/fcell.2020.568894 Text en Copyright © 2020 Moqbel, Xu, Chen, Xu, He, Wu, Ma, Ran, Wu and Xiong. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Moqbel, Safwat Adel Abdo Xu, Kai Chen, Zhonggai Xu, Langhai He, Yuezhe Wu, Zhipeng Ma, Chiyuan Ran, Jisheng Wu, Lidong Xiong, Yan Tectorigenin Alleviates Inflammation, Apoptosis, and Ossification in Rat Tendon-Derived Stem Cells via Modulating NF-Kappa B and MAPK Pathways |
title | Tectorigenin Alleviates Inflammation, Apoptosis, and Ossification in Rat Tendon-Derived Stem Cells via Modulating NF-Kappa B and MAPK Pathways |
title_full | Tectorigenin Alleviates Inflammation, Apoptosis, and Ossification in Rat Tendon-Derived Stem Cells via Modulating NF-Kappa B and MAPK Pathways |
title_fullStr | Tectorigenin Alleviates Inflammation, Apoptosis, and Ossification in Rat Tendon-Derived Stem Cells via Modulating NF-Kappa B and MAPK Pathways |
title_full_unstemmed | Tectorigenin Alleviates Inflammation, Apoptosis, and Ossification in Rat Tendon-Derived Stem Cells via Modulating NF-Kappa B and MAPK Pathways |
title_short | Tectorigenin Alleviates Inflammation, Apoptosis, and Ossification in Rat Tendon-Derived Stem Cells via Modulating NF-Kappa B and MAPK Pathways |
title_sort | tectorigenin alleviates inflammation, apoptosis, and ossification in rat tendon-derived stem cells via modulating nf-kappa b and mapk pathways |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7642480/ https://www.ncbi.nlm.nih.gov/pubmed/33195199 http://dx.doi.org/10.3389/fcell.2020.568894 |
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