Disease Phenotypes and Mechanisms of iPSC-Derived Cardiomyocytes From Brugada Syndrome Patients With a Loss-of-Function SCN5A Mutation

Brugada syndrome (BrS) is one of the major causes of sudden cardiac death in young people, while the underlying mechanisms are not completely understood. Here, we investigated the pathophysiological phenotypes and mechanisms using induced pluripotent stem cell (iPSC)-derived cardiomyocytes (CMs) fro...

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Detalles Bibliográficos
Autores principales: Li, Wener, Stauske, Michael, Luo, Xiaojing, Wagner, Stefan, Vollrath, Meike, Mehnert, Carola S., Schubert, Mario, Cyganek, Lukas, Chen, Simin, Hasheminasab, Sayed-Mohammad, Wulf, Gerald, El-Armouche, Ali, Maier, Lars S., Hasenfuss, Gerd, Guan, Kaomei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7642519/
https://www.ncbi.nlm.nih.gov/pubmed/33195263
http://dx.doi.org/10.3389/fcell.2020.592893

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