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Median Nerve-Neurophysiological Index Correlates With the Survival of Patients With Amyotrophic Lateral Sclerosis
Objective: This study aims to explore the association between median nerve-neurophysiological index (NI) and survival of patients with amyotrophic lateral sclerosis (ALS). Methods: A retrospective case series with a prospective follow-up study was performed in 238 patients with ALS. Their clinical p...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7642643/ https://www.ncbi.nlm.nih.gov/pubmed/33193014 http://dx.doi.org/10.3389/fneur.2020.570227 |
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author | Xu, Liu-Qing Hu, Wei Guo, Qi-Fu Lai, Lu-Lu Xu, Guo-Rong Chen, Wan-Jin Wang, Ning Zhang, Qi-Jie |
author_facet | Xu, Liu-Qing Hu, Wei Guo, Qi-Fu Lai, Lu-Lu Xu, Guo-Rong Chen, Wan-Jin Wang, Ning Zhang, Qi-Jie |
author_sort | Xu, Liu-Qing |
collection | PubMed |
description | Objective: This study aims to explore the association between median nerve-neurophysiological index (NI) and survival of patients with amyotrophic lateral sclerosis (ALS). Methods: A retrospective case series with a prospective follow-up study was performed in 238 patients with ALS. Their clinical profiles and NI were recorded. Kaplan-Meier curves and Cox regression were adopted to perform survival analysis. Results: The median survival time of all ALS cases was 33.0 months. Multivariate analysis showed that older age of onset, shorter diagnostic delay, higher ΔALSFRS-R, and faster progression {NI ≤ 2.15; hazard ratio [HR] = 1.543 [95% confidence interval (CI), 1.136–2.094]} were associated with short survival. NI was correlated with ALSFRS-R at baseline (r(s) = 0.3153; p < 0.0001) and ALSFRS-R at different time points of follow-up (r(s) = 0.5127; p < 0.0001). The higher NI slope of decline (> 0.25) showed shorter survival compared with the lower group (≤ 0.25; 34.0 vs. 52.0 months; p = 0.0003). A predictive model was constructed based on the age of onset, diagnostic delay, median nerve NI, and ΔALSFRS-R. The higher predictive score (> 14) showed significantly shorter survival compared with the lower group (≤ 14; HR = 3.907, 95% CI, 2.857–5.342). Conclusion: Median nerve NI and its slope of decline were predictive of survival of ALS. |
format | Online Article Text |
id | pubmed-7642643 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-76426432020-11-13 Median Nerve-Neurophysiological Index Correlates With the Survival of Patients With Amyotrophic Lateral Sclerosis Xu, Liu-Qing Hu, Wei Guo, Qi-Fu Lai, Lu-Lu Xu, Guo-Rong Chen, Wan-Jin Wang, Ning Zhang, Qi-Jie Front Neurol Neurology Objective: This study aims to explore the association between median nerve-neurophysiological index (NI) and survival of patients with amyotrophic lateral sclerosis (ALS). Methods: A retrospective case series with a prospective follow-up study was performed in 238 patients with ALS. Their clinical profiles and NI were recorded. Kaplan-Meier curves and Cox regression were adopted to perform survival analysis. Results: The median survival time of all ALS cases was 33.0 months. Multivariate analysis showed that older age of onset, shorter diagnostic delay, higher ΔALSFRS-R, and faster progression {NI ≤ 2.15; hazard ratio [HR] = 1.543 [95% confidence interval (CI), 1.136–2.094]} were associated with short survival. NI was correlated with ALSFRS-R at baseline (r(s) = 0.3153; p < 0.0001) and ALSFRS-R at different time points of follow-up (r(s) = 0.5127; p < 0.0001). The higher NI slope of decline (> 0.25) showed shorter survival compared with the lower group (≤ 0.25; 34.0 vs. 52.0 months; p = 0.0003). A predictive model was constructed based on the age of onset, diagnostic delay, median nerve NI, and ΔALSFRS-R. The higher predictive score (> 14) showed significantly shorter survival compared with the lower group (≤ 14; HR = 3.907, 95% CI, 2.857–5.342). Conclusion: Median nerve NI and its slope of decline were predictive of survival of ALS. Frontiers Media S.A. 2020-10-22 /pmc/articles/PMC7642643/ /pubmed/33193014 http://dx.doi.org/10.3389/fneur.2020.570227 Text en Copyright © 2020 Xu, Hu, Guo, Lai, Xu, Chen, Wang and Zhang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neurology Xu, Liu-Qing Hu, Wei Guo, Qi-Fu Lai, Lu-Lu Xu, Guo-Rong Chen, Wan-Jin Wang, Ning Zhang, Qi-Jie Median Nerve-Neurophysiological Index Correlates With the Survival of Patients With Amyotrophic Lateral Sclerosis |
title | Median Nerve-Neurophysiological Index Correlates With the Survival of Patients With Amyotrophic Lateral Sclerosis |
title_full | Median Nerve-Neurophysiological Index Correlates With the Survival of Patients With Amyotrophic Lateral Sclerosis |
title_fullStr | Median Nerve-Neurophysiological Index Correlates With the Survival of Patients With Amyotrophic Lateral Sclerosis |
title_full_unstemmed | Median Nerve-Neurophysiological Index Correlates With the Survival of Patients With Amyotrophic Lateral Sclerosis |
title_short | Median Nerve-Neurophysiological Index Correlates With the Survival of Patients With Amyotrophic Lateral Sclerosis |
title_sort | median nerve-neurophysiological index correlates with the survival of patients with amyotrophic lateral sclerosis |
topic | Neurology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7642643/ https://www.ncbi.nlm.nih.gov/pubmed/33193014 http://dx.doi.org/10.3389/fneur.2020.570227 |
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