Monocyte Transmodulation: The Next Novel Therapeutic Approach in Overcoming Ischemic Stroke?

The immune response following neuroinflammation is a vital element of ischemic stroke pathophysiology. After the onset of ischemic stroke, a specialized vasculature system that effectively protects central nervous system tissues from the invasion of blood cells and other macromolecules is broken dow...

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Autores principales: Park, Joohyun, Chang, Ji Young, Kim, Jong Youl, Lee, Jong Eun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7642685/
https://www.ncbi.nlm.nih.gov/pubmed/33193029
http://dx.doi.org/10.3389/fneur.2020.578003
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author Park, Joohyun
Chang, Ji Young
Kim, Jong Youl
Lee, Jong Eun
author_facet Park, Joohyun
Chang, Ji Young
Kim, Jong Youl
Lee, Jong Eun
author_sort Park, Joohyun
collection PubMed
description The immune response following neuroinflammation is a vital element of ischemic stroke pathophysiology. After the onset of ischemic stroke, a specialized vasculature system that effectively protects central nervous system tissues from the invasion of blood cells and other macromolecules is broken down within minutes, thereby triggering the inflammation cascade, including the infiltration of peripheral blood leukocytes. In this series of processes, blood-derived monocytes have a significant effect on the outcome of ischemic stroke through neuroinflammatory responses. As neuroinflammation is a necessary and pivotal component of the reparative process after ischemic stroke, understanding the role of infiltrating monocytes in the modulation of inflammatory responses may offer a great opportunity to explore new therapies for ischemic stroke. In this review, we discuss and highlight the function and involvement of monocytes in the brain after ischemic injury, as well as their impact on tissue damage and repair.
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spelling pubmed-76426852020-11-13 Monocyte Transmodulation: The Next Novel Therapeutic Approach in Overcoming Ischemic Stroke? Park, Joohyun Chang, Ji Young Kim, Jong Youl Lee, Jong Eun Front Neurol Neurology The immune response following neuroinflammation is a vital element of ischemic stroke pathophysiology. After the onset of ischemic stroke, a specialized vasculature system that effectively protects central nervous system tissues from the invasion of blood cells and other macromolecules is broken down within minutes, thereby triggering the inflammation cascade, including the infiltration of peripheral blood leukocytes. In this series of processes, blood-derived monocytes have a significant effect on the outcome of ischemic stroke through neuroinflammatory responses. As neuroinflammation is a necessary and pivotal component of the reparative process after ischemic stroke, understanding the role of infiltrating monocytes in the modulation of inflammatory responses may offer a great opportunity to explore new therapies for ischemic stroke. In this review, we discuss and highlight the function and involvement of monocytes in the brain after ischemic injury, as well as their impact on tissue damage and repair. Frontiers Media S.A. 2020-10-22 /pmc/articles/PMC7642685/ /pubmed/33193029 http://dx.doi.org/10.3389/fneur.2020.578003 Text en Copyright © 2020 Park, Chang, Kim and Lee. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Park, Joohyun
Chang, Ji Young
Kim, Jong Youl
Lee, Jong Eun
Monocyte Transmodulation: The Next Novel Therapeutic Approach in Overcoming Ischemic Stroke?
title Monocyte Transmodulation: The Next Novel Therapeutic Approach in Overcoming Ischemic Stroke?
title_full Monocyte Transmodulation: The Next Novel Therapeutic Approach in Overcoming Ischemic Stroke?
title_fullStr Monocyte Transmodulation: The Next Novel Therapeutic Approach in Overcoming Ischemic Stroke?
title_full_unstemmed Monocyte Transmodulation: The Next Novel Therapeutic Approach in Overcoming Ischemic Stroke?
title_short Monocyte Transmodulation: The Next Novel Therapeutic Approach in Overcoming Ischemic Stroke?
title_sort monocyte transmodulation: the next novel therapeutic approach in overcoming ischemic stroke?
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7642685/
https://www.ncbi.nlm.nih.gov/pubmed/33193029
http://dx.doi.org/10.3389/fneur.2020.578003
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