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Cortisone and cortisol break hydrogen-bonding rules to make a drug–prodrug solid solution

Multidrug products enable more effective therapies and simpler administration regimens, provided that a stable formulation is prepared, with the desired composition. In this view, solid solutions have the advantage of combining the stability of a single crystalline phase with the potential of stoich...

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Autores principales: Verma, Vivek, Bordignon, Simone, Chierotti, Michele R., Lestari, Monica, Lyons, Kieran, Padrela, Luis, Ryan, Kevin M., Lusi, Matteo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7642785/
https://www.ncbi.nlm.nih.gov/pubmed/33209323
http://dx.doi.org/10.1107/S2052252520013263
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author Verma, Vivek
Bordignon, Simone
Chierotti, Michele R.
Lestari, Monica
Lyons, Kieran
Padrela, Luis
Ryan, Kevin M.
Lusi, Matteo
author_facet Verma, Vivek
Bordignon, Simone
Chierotti, Michele R.
Lestari, Monica
Lyons, Kieran
Padrela, Luis
Ryan, Kevin M.
Lusi, Matteo
author_sort Verma, Vivek
collection PubMed
description Multidrug products enable more effective therapies and simpler administration regimens, provided that a stable formulation is prepared, with the desired composition. In this view, solid solutions have the advantage of combining the stability of a single crystalline phase with the potential of stoichiometry variation of a mixture. Here a drug–prodrug solid solution of cortisone and cortisol (hydrocortisone) is described. Despite the structural differences of the two components, the new phase is obtained both from solution and by supercritical CO(2) assisted spray drying. In particular, to enter the solid solution, hydrocortisone must violate Etter’s rules for hydrogen bonding. As a result, its dissolution rate is almost doubled.
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spelling pubmed-76427852020-11-17 Cortisone and cortisol break hydrogen-bonding rules to make a drug–prodrug solid solution Verma, Vivek Bordignon, Simone Chierotti, Michele R. Lestari, Monica Lyons, Kieran Padrela, Luis Ryan, Kevin M. Lusi, Matteo IUCrJ Research Papers Multidrug products enable more effective therapies and simpler administration regimens, provided that a stable formulation is prepared, with the desired composition. In this view, solid solutions have the advantage of combining the stability of a single crystalline phase with the potential of stoichiometry variation of a mixture. Here a drug–prodrug solid solution of cortisone and cortisol (hydrocortisone) is described. Despite the structural differences of the two components, the new phase is obtained both from solution and by supercritical CO(2) assisted spray drying. In particular, to enter the solid solution, hydrocortisone must violate Etter’s rules for hydrogen bonding. As a result, its dissolution rate is almost doubled. International Union of Crystallography 2020-10-23 /pmc/articles/PMC7642785/ /pubmed/33209323 http://dx.doi.org/10.1107/S2052252520013263 Text en © Verma et al. 2020 http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC-BY) Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.http://creativecommons.org/licenses/by/4.0/
spellingShingle Research Papers
Verma, Vivek
Bordignon, Simone
Chierotti, Michele R.
Lestari, Monica
Lyons, Kieran
Padrela, Luis
Ryan, Kevin M.
Lusi, Matteo
Cortisone and cortisol break hydrogen-bonding rules to make a drug–prodrug solid solution
title Cortisone and cortisol break hydrogen-bonding rules to make a drug–prodrug solid solution
title_full Cortisone and cortisol break hydrogen-bonding rules to make a drug–prodrug solid solution
title_fullStr Cortisone and cortisol break hydrogen-bonding rules to make a drug–prodrug solid solution
title_full_unstemmed Cortisone and cortisol break hydrogen-bonding rules to make a drug–prodrug solid solution
title_short Cortisone and cortisol break hydrogen-bonding rules to make a drug–prodrug solid solution
title_sort cortisone and cortisol break hydrogen-bonding rules to make a drug–prodrug solid solution
topic Research Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7642785/
https://www.ncbi.nlm.nih.gov/pubmed/33209323
http://dx.doi.org/10.1107/S2052252520013263
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