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Association Between Psoriasis and Dementia: Current Evidence

Background: Psoriasis and dementia are both inflammatory diseases. The association between psoriasis and dementia has rarely been investigated, and the existing results are conflicting. Thus, we conducted this study to evaluate whether an association exists between psoriasis and dementia. Methods: W...

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Autores principales: Liu, Liu, Chen, Si-ting, Li, Hong-jin, Qiang, Yan, Sun, Xiao-ying, Zhou, Ya-qiong, Xing, Meng, Luo, Ying, Ru, Yi, Ding, Xiao-jie, Kuai, Le, Li, Bin, Li, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7642958/
https://www.ncbi.nlm.nih.gov/pubmed/33192461
http://dx.doi.org/10.3389/fnagi.2020.570992
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author Liu, Liu
Chen, Si-ting
Li, Hong-jin
Qiang, Yan
Sun, Xiao-ying
Zhou, Ya-qiong
Xing, Meng
Luo, Ying
Ru, Yi
Ding, Xiao-jie
Kuai, Le
Li, Bin
Li, Xin
author_facet Liu, Liu
Chen, Si-ting
Li, Hong-jin
Qiang, Yan
Sun, Xiao-ying
Zhou, Ya-qiong
Xing, Meng
Luo, Ying
Ru, Yi
Ding, Xiao-jie
Kuai, Le
Li, Bin
Li, Xin
author_sort Liu, Liu
collection PubMed
description Background: Psoriasis and dementia are both inflammatory diseases. The association between psoriasis and dementia has rarely been investigated, and the existing results are conflicting. Thus, we conducted this study to evaluate whether an association exists between psoriasis and dementia. Methods: We searched for studies from six databases from inception to July 30, 2020, using subject and free words. RevMan 5.4 was used to calculate the risk ratio (RR) of dementia in the subjects with psoriasis. When heterogeneity was present, a random-effects model was used. Subgroup, sensitivity, and meta-regression analyses were performed using Stata 15.1. Results: Nine studies were identified and included in the study, of which seven that involved a total of 3,638,487 participants were included in the meta-analysis. We found that among the patients with psoriasis (RR: 1.14, 95% confidence interval [CI]: 1.06–1.24, p = 0.0009) and psoriatic arthritis (RR: 2.20, 95% CI: 1.29–3.78, p = 0.004), the proportions of those with non-vascular dementia (RR: 1.13, 95% CI: 1.11–1.15, p < 0.00001) and vascular dementia (RR: 1.41, 95% CI: 1.09–1.82, p = 0.009) were higher than that among the patients without psoriasis. Those with dementia were also more likely to develop psoriasis, and those with severe psoriasis were less likely to die from dementia (RR: 1.88, 95% CI: 0.72–4.90, p = 0.020). The meta-regression analysis did not show any significant sources of heterogeneity. Conclusions: The patients with psoriasis and psoriatic arthritis show high prevalence of different types of dementia. Based on the findings of this study, dementia may not be considered a high-risk factor of death from severe psoriasis. However, identification of this potential risk allows for early intervention, thereby reducing comorbidities and deaths.
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spelling pubmed-76429582020-11-13 Association Between Psoriasis and Dementia: Current Evidence Liu, Liu Chen, Si-ting Li, Hong-jin Qiang, Yan Sun, Xiao-ying Zhou, Ya-qiong Xing, Meng Luo, Ying Ru, Yi Ding, Xiao-jie Kuai, Le Li, Bin Li, Xin Front Aging Neurosci Neuroscience Background: Psoriasis and dementia are both inflammatory diseases. The association between psoriasis and dementia has rarely been investigated, and the existing results are conflicting. Thus, we conducted this study to evaluate whether an association exists between psoriasis and dementia. Methods: We searched for studies from six databases from inception to July 30, 2020, using subject and free words. RevMan 5.4 was used to calculate the risk ratio (RR) of dementia in the subjects with psoriasis. When heterogeneity was present, a random-effects model was used. Subgroup, sensitivity, and meta-regression analyses were performed using Stata 15.1. Results: Nine studies were identified and included in the study, of which seven that involved a total of 3,638,487 participants were included in the meta-analysis. We found that among the patients with psoriasis (RR: 1.14, 95% confidence interval [CI]: 1.06–1.24, p = 0.0009) and psoriatic arthritis (RR: 2.20, 95% CI: 1.29–3.78, p = 0.004), the proportions of those with non-vascular dementia (RR: 1.13, 95% CI: 1.11–1.15, p < 0.00001) and vascular dementia (RR: 1.41, 95% CI: 1.09–1.82, p = 0.009) were higher than that among the patients without psoriasis. Those with dementia were also more likely to develop psoriasis, and those with severe psoriasis were less likely to die from dementia (RR: 1.88, 95% CI: 0.72–4.90, p = 0.020). The meta-regression analysis did not show any significant sources of heterogeneity. Conclusions: The patients with psoriasis and psoriatic arthritis show high prevalence of different types of dementia. Based on the findings of this study, dementia may not be considered a high-risk factor of death from severe psoriasis. However, identification of this potential risk allows for early intervention, thereby reducing comorbidities and deaths. Frontiers Media S.A. 2020-10-22 /pmc/articles/PMC7642958/ /pubmed/33192461 http://dx.doi.org/10.3389/fnagi.2020.570992 Text en Copyright © 2020 Liu, Chen, Li, Qiang, Sun, Zhou, Xing, Luo, Ru, Ding, Kuai, Li and Li. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Liu, Liu
Chen, Si-ting
Li, Hong-jin
Qiang, Yan
Sun, Xiao-ying
Zhou, Ya-qiong
Xing, Meng
Luo, Ying
Ru, Yi
Ding, Xiao-jie
Kuai, Le
Li, Bin
Li, Xin
Association Between Psoriasis and Dementia: Current Evidence
title Association Between Psoriasis and Dementia: Current Evidence
title_full Association Between Psoriasis and Dementia: Current Evidence
title_fullStr Association Between Psoriasis and Dementia: Current Evidence
title_full_unstemmed Association Between Psoriasis and Dementia: Current Evidence
title_short Association Between Psoriasis and Dementia: Current Evidence
title_sort association between psoriasis and dementia: current evidence
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7642958/
https://www.ncbi.nlm.nih.gov/pubmed/33192461
http://dx.doi.org/10.3389/fnagi.2020.570992
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