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Evaluation of cytokine expression and circulating immune cell subsets as potential parameters of acute radiation toxicity in prostate cancer patients

One of the challenges of radiation oncology in the era of personalized medicine is identification of biomarkers associated with individual radiosensitivity. The aim of research was to evaluate the possible clinical value of the associations between clinical, physical, and biological factors, and ris...

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Autores principales: Stanojković, Tatjana P., Matić, Ivana Z., Petrović, Nina, Stanković, Vesna, Kopčalić, Katarina, Besu, Irina, Đorđić Crnogorac, Marija, Mališić, Emina, Mirjačić-Martinović, Katarina, Vuletić, Ana, Bukumirić, Zoran, Žižak, Željko, Veldwijk, Marlon, Herskind, Carsten, Nikitović, Marina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7643057/
https://www.ncbi.nlm.nih.gov/pubmed/33149212
http://dx.doi.org/10.1038/s41598-020-75812-0
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author Stanojković, Tatjana P.
Matić, Ivana Z.
Petrović, Nina
Stanković, Vesna
Kopčalić, Katarina
Besu, Irina
Đorđić Crnogorac, Marija
Mališić, Emina
Mirjačić-Martinović, Katarina
Vuletić, Ana
Bukumirić, Zoran
Žižak, Željko
Veldwijk, Marlon
Herskind, Carsten
Nikitović, Marina
author_facet Stanojković, Tatjana P.
Matić, Ivana Z.
Petrović, Nina
Stanković, Vesna
Kopčalić, Katarina
Besu, Irina
Đorđić Crnogorac, Marija
Mališić, Emina
Mirjačić-Martinović, Katarina
Vuletić, Ana
Bukumirić, Zoran
Žižak, Željko
Veldwijk, Marlon
Herskind, Carsten
Nikitović, Marina
author_sort Stanojković, Tatjana P.
collection PubMed
description One of the challenges of radiation oncology in the era of personalized medicine is identification of biomarkers associated with individual radiosensitivity. The aim of research was to evaluate the possible clinical value of the associations between clinical, physical, and biological factors, and risk for development of acute radiotoxicity in patients with prostate cancer. The study involved forty four patients treated with three-dimensional conformal radiotherapy. The concentrations of IL-1β, IL-2, IL-6, IFN-γ and TGF-β1 were assessed before radiotherapy, after 5th, 15th and 25th radiotherapy fractions, at the end, and 1 month after the end of radiotherapy. Cytokine gene expression was determined in peripheral blood mononuclear cells. The univariate analysis of circulating cytokine levels during radiotherapy showed that increased serum concentrations of IL-6 were significantly associated with higher grade of acute genitourinary toxicity. The multivariate analysis demonstrated that increased level of IL-6 during the radiotherapy was significantly associated with higher grade of acute genitourinary toxicity across treatment. TGF-β expression levels significantly decreased during course of radiotherapy. Research indicates that changes in circulating cytokine levels might be important parameter of radiotoxicity in patients with prostate cancer. These findings suggest that future studies based on multi-parameter examination are necessary for prediction of individual radiosensitivity.
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spelling pubmed-76430572020-11-06 Evaluation of cytokine expression and circulating immune cell subsets as potential parameters of acute radiation toxicity in prostate cancer patients Stanojković, Tatjana P. Matić, Ivana Z. Petrović, Nina Stanković, Vesna Kopčalić, Katarina Besu, Irina Đorđić Crnogorac, Marija Mališić, Emina Mirjačić-Martinović, Katarina Vuletić, Ana Bukumirić, Zoran Žižak, Željko Veldwijk, Marlon Herskind, Carsten Nikitović, Marina Sci Rep Article One of the challenges of radiation oncology in the era of personalized medicine is identification of biomarkers associated with individual radiosensitivity. The aim of research was to evaluate the possible clinical value of the associations between clinical, physical, and biological factors, and risk for development of acute radiotoxicity in patients with prostate cancer. The study involved forty four patients treated with three-dimensional conformal radiotherapy. The concentrations of IL-1β, IL-2, IL-6, IFN-γ and TGF-β1 were assessed before radiotherapy, after 5th, 15th and 25th radiotherapy fractions, at the end, and 1 month after the end of radiotherapy. Cytokine gene expression was determined in peripheral blood mononuclear cells. The univariate analysis of circulating cytokine levels during radiotherapy showed that increased serum concentrations of IL-6 were significantly associated with higher grade of acute genitourinary toxicity. The multivariate analysis demonstrated that increased level of IL-6 during the radiotherapy was significantly associated with higher grade of acute genitourinary toxicity across treatment. TGF-β expression levels significantly decreased during course of radiotherapy. Research indicates that changes in circulating cytokine levels might be important parameter of radiotoxicity in patients with prostate cancer. These findings suggest that future studies based on multi-parameter examination are necessary for prediction of individual radiosensitivity. Nature Publishing Group UK 2020-11-04 /pmc/articles/PMC7643057/ /pubmed/33149212 http://dx.doi.org/10.1038/s41598-020-75812-0 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Stanojković, Tatjana P.
Matić, Ivana Z.
Petrović, Nina
Stanković, Vesna
Kopčalić, Katarina
Besu, Irina
Đorđić Crnogorac, Marija
Mališić, Emina
Mirjačić-Martinović, Katarina
Vuletić, Ana
Bukumirić, Zoran
Žižak, Željko
Veldwijk, Marlon
Herskind, Carsten
Nikitović, Marina
Evaluation of cytokine expression and circulating immune cell subsets as potential parameters of acute radiation toxicity in prostate cancer patients
title Evaluation of cytokine expression and circulating immune cell subsets as potential parameters of acute radiation toxicity in prostate cancer patients
title_full Evaluation of cytokine expression and circulating immune cell subsets as potential parameters of acute radiation toxicity in prostate cancer patients
title_fullStr Evaluation of cytokine expression and circulating immune cell subsets as potential parameters of acute radiation toxicity in prostate cancer patients
title_full_unstemmed Evaluation of cytokine expression and circulating immune cell subsets as potential parameters of acute radiation toxicity in prostate cancer patients
title_short Evaluation of cytokine expression and circulating immune cell subsets as potential parameters of acute radiation toxicity in prostate cancer patients
title_sort evaluation of cytokine expression and circulating immune cell subsets as potential parameters of acute radiation toxicity in prostate cancer patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7643057/
https://www.ncbi.nlm.nih.gov/pubmed/33149212
http://dx.doi.org/10.1038/s41598-020-75812-0
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