Small molecules as potent biphasic modulators of protein liquid-liquid phase separation

Liquid-liquid phase separation (LLPS) of proteins that leads to formation of membrane-less organelles is critical to many biochemical processes in the cell. However, dysregulated LLPS can also facilitate aberrant phase transitions and lead to protein aggregation and disease. Accordingly, there is gr...

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Detalles Bibliográficos
Autores principales: Babinchak, W. Michael, Dumm, Benjamin K., Venus, Sarah, Boyko, Solomiia, Putnam, Andrea A., Jankowsky, Eckhard, Surewicz, Witold K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7643064/
https://www.ncbi.nlm.nih.gov/pubmed/33149109
http://dx.doi.org/10.1038/s41467-020-19211-z

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