Type I IFN exacerbates disease in tuberculosis-susceptible mice by inducing neutrophil-mediated lung inflammation and NETosis

Tuberculosis (TB) is a leading cause of mortality due to infectious disease, but the factors determining disease progression are unclear. Transcriptional signatures associated with type I IFN signalling and neutrophilic inflammation were shown to correlate with disease severity in mouse models of TB...

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Detalles Bibliográficos
Autores principales: Moreira-Teixeira, Lúcia, Stimpson, Philippa J., Stavropoulos, Evangelos, Hadebe, Sabelo, Chakravarty, Probir, Ioannou, Marianna, Aramburu, Iker Valle, Herbert, Eleanor, Priestnall, Simon L., Suarez-Bonnet, Alejandro, Sousa, Jeremy, Fonseca, Kaori L., Wang, Qian, Vashakidze, Sergo, Rodríguez-Martínez, Paula, Vilaplana, Cristina, Saraiva, Margarida, Papayannopoulos, Venizelos, O’Garra, Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7643080/
https://www.ncbi.nlm.nih.gov/pubmed/33149141
http://dx.doi.org/10.1038/s41467-020-19412-6

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