Decacationic Pillar[5]arene: A New Scaffold for the Development of (129)Xe MRI Imaging Agents

[Image: see text] A decacationic water-soluble pillar[5]arene possessing a nonsolvated hydrophobic core has been designed and synthesized. This supramolecular host is capable of binding xenon, as evidenced by hyperCEST depletion experiments. Fluorescence-based studies also demonstrate that xenon bin...

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Detalles Bibliográficos
Autores principales: Fernando, P. U. Ashvin I., Shepelytskyi, Yurii, Cesana, Paul T., Wade, Alanna, Grynko, Vira, Mendieta, Adriana M., Seveney, Lauren E., Brown, Joseph D., Hane, Francis T., Albert, Mitchell S., DeBoef, Brenton
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7643082/
https://www.ncbi.nlm.nih.gov/pubmed/33163761
http://dx.doi.org/10.1021/acsomega.0c02565
Descripción
Sumario:[Image: see text] A decacationic water-soluble pillar[5]arene possessing a nonsolvated hydrophobic core has been designed and synthesized. This supramolecular host is capable of binding xenon, as evidenced by hyperCEST depletion experiments. Fluorescence-based studies also demonstrate that xenon binds into the cavity of the pillararene with an association constant of 4.6 × 10(3) M(–1). These data indicate that the water-soluble pillararene is a potential scaffold for building contrast agents that can be detected by xenon-129 magnetic resonance imaging.

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